Hypotensive Compounds Isolated from the Dried Body of Naja naja Kaouthia LESSON. I. : Isolation of Inosine as a HYpotensive Principle and Structure-Activity Study of Related Compounds

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概要

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• From the dried body of Naja naja Kaouthia from which the internal organs had been removed, three hypotensive compounds were isolated and one of them was identified as inosine.Inosine produced a transient increase in blood pressure followed by a prolonged fall lasting for 30 min in spontaneously hypertensive rats. Next, the relationship between the chemical structure and the hypotensive effect was examined by studying ribose-modified derivatives of inosine. 2'-Deoxyinosine and 3'-deoxyinosine completely lacked hypotensive effect. Phosphorylation at the 3' or 5'-position except for inosine 5'-diphosphoribose and 5'-chloro-5'-deoxyinosine slightly decreased the hypotensive effect. The results indicate that the ribose configuration is important in relation to the hypotensive effect of inosine.

• 公益社団法人日本薬学会の論文
• 1986-04-25

著者

• 久保 真百合

  Osaka University of Pharmaceutical Sciences

• 谷口 暢

  Osaka University, of Pharamaceutical Sciences

• 辻坊 裕

  大阪薬大

• 谷口 暢

  Osaka University Of Pharamaceutical Sciences

• 辻坊 裕

  Oska College of Pharmacy

• 谷口 暢

  Oska College of Pharmacy

• 小山 勲

  Oska College of Pharmacy

• 久保 真百合

  Oska College of Pharmacy

• 稲森 善彦

  Oska College of Pharmacy

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