EFFECT OF 3,3'-DIHYDROXY-α, β-DIETHYLDIPHENYLETHANE ON CORONARY AND MESENTERIC ARTERIES ISOLATED FROM GUINEA-PIGS
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概要
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3,3'-Dihydroxy-α, β-diethyldiphenylethane (I__-), the isomer of hexestrol (<II>___-), showed strong coronary vasodilator effect (ED_<50> : 1.0 μg/heart) on the isolated quinea-pig heart. The action of I__- was stronger than those of <II>___-(ED_<50> : 9.0 μg/heart) and 3,3'-dihydroxy-α, β-diethylstilbene (ED_<50> : 4.3 μg/heart), the starting material of I__-. Compound I__- also had a carditonic effect and a relaxing action on the contraction of guinea-pig mesenteric artery due to KCl and norepinephirne at a low concentration of 10^<-6>-10^<-5>M. It should be emphasized that compound I__-, in addition to the lack of hormonal side effect, had a stronger effect on guinea-pig coronary and mesenteric artery.
- 公益社団法人日本薬学会の論文
- 1988-03-25
著者
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竹村 庄司
Faculty Of Pharmaceutical Sciences Kinki University
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稲森 善彦
Osaka University of Pharmaceutical Sciences
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辻坊 裕
Osaka University of Pharmaceutical Sciences
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辻坊 裕
大阪薬大
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三木 康義
近畿大学 薬学部
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竹村 庄司
Faculty of Pharmaceutical Sciences, Kinki University
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