Antimicrobial Activity on Plant-Pathogenic Microorganisms and Phytogrowth-Inhibitory Activity of Streptothricin Antibiotics, Racemomycin-A and -C
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概要
- 論文の詳細を見る
Streptothricin antibiotics, racemomycin-A and -C(RM-A and -C), which contain one and two β-lysine moieties in the molecule, were found to show antimicrobial activity on plant-pathogenic microorganisms and phytogrowth-inhibitory activity.RN-A and -C showed antimicrobial activities against all the plant-pathogenic microorganisms tested. In particular, RM-C showed strong antifungal activity on Fusarium oxysporum f. sp. lycopersici IFO-6531 (minimal inhibitory concentration (MIC) : 3.0 μg/ml). Both antibiotics storongly inhibited the growth of the root of Brassica rapa L. even at the low concentration of 50 ppm. These activities of RM-C were slightly stronger than those of RM-A. This would indicated that the β-lysine moiety in the molecule plays some role in the activity of streptothricin antibiotics.On the other hand, racemomycinic-A-acid (RM-A-acid), produced by opening the lactam ring of the streptolidine moiety of RM-A, did not show any of the above-mentioned activities. This would suggest a close relationship betweem the streptolidine moiety in the molecule of streptothricin antibiotics and the activities.
- 社団法人日本薬学会の論文
- 1988-04-25
著者
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稲森 善彦
Osaka University of Pharmaceutical Sciences
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辻坊 裕
Osaka University of Pharmaceutical Sciences
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佐藤 浩史
Osaka University Of Pharamaceutical Sciences
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富永 裕子
Osaka University of Pharmaceutical Sciences
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奥野 誠
Osaka University of Pharmaceutical Sciences
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辻坊 裕
大阪薬大
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