The Hypotensive Effect and Antifungal Activity of 3,3'-Dihydroxy-α, β-diethyldiphenylethane

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概要

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• 3,3'-Dihydroxy-α, β-diethyldiphenylethane (I), an isomer of hexestrol (II), was found to have a strong hypotensive effect on rats and antifungal activity against some pathogenic fungi. The hypotensive effect of I (-100.0±21.0mmHg, 10mg/kg, i.v.) was stronger than that of II (-40.0±2.60mmHg, i.v.). Unlike II and other oxystilbene-related compounds already tested, I showed prolonged hypotensive action at the dose of 10mg/kg, and the blood pressure was not restored to the original level within 20min. I also showed antifungal activity against all fungi tested (minimal inhibitory concentration : 10-120μg/ml). It should be emphasized that by shifting the phenolic hydroxyl group to m-position, the biological activities were greatly increased.

• 社団法人日本薬学会の論文
• 1989-11-25

著者

• 竹村 庄司

  Faculty Of Pharmaceutical Sciences Kinki University

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 小川 雅史

  Osaka University Of Pharmaceutical Sciences

• 三木 康義

  Faculty of Pharmaceutical Sciences, Kinki University

• 大野 由美子

  Osaka University of Pharmaceutical Sciences

• 西畑 秀一

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  大阪薬大

• 三木 康義

  Faculty Of Pharmaceutical Sciences Kinki University

• 三木 康義

  近畿大学 薬学部

• 竹村 庄司

  Faculty of Pharmaceutical Sciences, Kinki University

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