Studies on Benzhydryl Derivatives. I. Synthesis and Anti-Inflammatory Activity

スポンサーリンク

概要

• 論文の詳細を見る

• A series of N-diphenylmethyl derivatives of glycine was synthesized and their anti-inflammatory and some other pharmacological properties were studied. The inhibition of carrageenin edema-induction and the protection of albumin from heat denaturation by these derivatives were studied in relation to the substituents in one of the phenyl groups. The most potent compounds, 3,4-dichloro-(Compd. 22) and 4-fluoro-(Compd. 16) diphenylmethylglycine derivatives, showed the higher activity in carrageenin-edema and weaker toxicity tested by gastric irritation and acute toxicity study than 2-(4-isobutyl-phenyl) propionic acid (ibuprofen). Compd. 16 showed the significant and interesting synergic effect by co-administration with cortisone acetate in the various tests of anti-inflammatory activity.

• 1979-04-25

著者

• 竹村 庄司

  Faculty Of Pharmaceutical Sciences Kinki University

• 安井 凡平

  General Research Center, Funai Pharmaceutical Co., Ltd.

• 安藤 和子

  General Research Center Funai Pharmaceutical Co. Ltd.

• 安井 凡平

  General Research Center Funai Pharmaceutical Co. Ltd.

• 永富 光

  General Research Center Funai Pharmaceutical Co. Ltd.

関連論文

• Phytogrowth-Inhibitory and Antimicrobial Activities of 3,4'-Dihydroxy-α, β-diethylstilbene, the Isomer of Diethylstilbestrol
• Hypotensive Effects on Spontaneously Hypertensive Rats and Antifungal Activity on Various Species of Fusarium oxysporum of Diethylstilbestrol-Related Compounds
• The Hypotensive Effect and Antifungal Activity of 3,3'-Dihydroxy-α, β-diethyldiphenylethane
• Antifungal Activity against Plant-Pathogenic Fungi and Phytogrowth-Inhibitory Activity of 3,3'-Dihydroxy-α, β-diethyldiphenylethane
• THE ICHTHYOTOXICITY AND CORONARY VASODILATOR ACTION OF 3,3'-DIHYDROXY-α,β-DIETHYLSTILBENE(Communications to the Editor)
• Synthesis and Bioactivity of Propranolol Analogues with a Rigid Skeleton. I
• Synthesis and Selective Activity of Cholinergic Agents with Rigid Skeletons. IV
• Synthesis and Selective Activity of Cholinergic Agents with Rigid Skeletons. III
• Synthesis and Selective Activity of Cholinergic Agents with Rigid Skeletons. II
• 降圧性コリン作働薬を目的とした合成(2)(II 予防および治療)(A 基礎的研究)
• 降圧性コリン作働薬を目的とした合成(A 基礎的研究)(II 予防および治療)
• Synthesis and Selective Activity of Cholinergic Agents with Rigid Skeletons. I
• Benzoylthiocholine Derivatives as Substrates for Pseudocholinesterase : Synthesis and Application(Analytical,Chemical)
• ベンズヒドリル誘導体の研究(第2報)N, N-ジアルキルグリシルベンズヒドリルアミド誘導体の合成と生物活性
• Reaction of N-Halosulfonamide. IV. A Cleavage Reaction of Ether with N, N-Dihalobenzenesulfonamide. (1).
• Reaction of N-Halosulfonamide. III. Reaction of N, N-Dibromobenzenesulfonamide with Cyclopentene.
• Reaction of DL-trans-and DL-cis-2-Halo-1-benzenesulfonamidocyclohexanes. Formation and the Reaction of N-Benzenesulfonylcyclohexenimine.
• Reaction of N-Halosulfonamide. II. Reaction of N, N-Dihalobenzenesulfonamide with Cyclohexene. (2).
• Reaction of N-Halosulfonamide. I. Reaction of N, N-Dihalobenzenesulfonamide with Cyclohexene. (1).
• Reaction of N, N-Dihalobenzenesulfonamide with Cyclohexene. Formation of DL-trans-and DL-cis-2-Halo-1-benzenesulfonamidocyclohexanes
• Reaction of 2-Methyl-4-phenyl-2,3-dihydro-1H-pyrazolo[2,3,4-de][1,5]-naphthyridine 2-Oxides with Acetic Anhydrides : Polonovski Reaction versus Mesomeric Betaine Formation
• Reaction of N-Haloamide. XIX. Reaction of Acetals with N, N-Dibromobenzenesulfonamide
• Reaction of N-Haloamide. XVIII. Oxidation of Ether to Ester with N-Haloamide
• Reaction of N-Haloamide. XV. Reaction of Tetrahydrofuran with N, N-Dibromobenzenesulfonamide. (2). Kinetics and Mechanism
• Kinetic Studies of the Reaction of Tetrahydrofuran with N-Haloamide under Irradiation
• Steroids from Cucumis Melo L. var. Makuwa MAKINO and Cucumis sativus L.
• Reaction of N-Haloamide. VIII. Reactions of N-Bromobenzenesulfonamides or Bromine with Benzylamines
• EFFECT OF 3,3'-DIHYDROXY-α, β-DIETHYLDIPHENYLETHANE ON CORONARY AND MESENTERIC ARTERIES ISOLATED FROM GUINEA-PIGS
• Studies on Benzhydryl Derivatives. IV. Synthesis and Anti-inflammatory Activity of 2-O-(Diphenylacetyl)salicylic Acids
• ベンズヒドリル誘導体の研究(第3報)ジフェニルアセチルアミノ酸の合成と培養腫瘍細胞におよぼす影響
• 降圧性を目的とした芳香族オキシカルボン酸誘導体の合成(1)(II 予防および治療)(A 基礎的研究)
• 降圧剤を目的としたBenzhydrylidene Guanidine類の合成と活性(II 予防および治療)(A 基礎的研究)
• コリン作働薬の分子座標解析法による構造-活性相関(A 基礎的研究)(II 予防および治療)
• アミノ酸誘導体と生物活性(第2報)フェニルアラニンから2-アミノ-1-インダノール誘導体の合成
• Reaction of N-Haloamide. XXVIII. Preparation of N, N-Dibromourethan and Reactions of N, N-Dihaloamides with Styrene and 1,2-Dihydronaphthalenes
• Reaction of N-Haloamide. XXVII. Reaction of N, N-Dihaloamides with Dienes
• Reaction of N-Haloamide. XXV. Addition Reaction of N, N-Di-bromobenzenesulfonamide with Asymmetric Olefins and α, β-Unsaturated Carboxylic Acid Esters
• Reaction of N-Haloamide. XXIV. N, N-Dibromo-o-carbomethoxybenzene-sulfonamide as a Reagent for the Preparation of β-Substituted Amines from Olefins
• Reaction of N-Haloamide. XXI. Addition Reaction of N, N-Dibromo-benzylsulfonamide with Olefines and Reduction of the Adducts and Their Derivatives
• Reaction of N-Haloamide. XX. Bromo-formyloxylation of α, β-Unsaturated Esters with N, N-Dibromobenzenesulfonamide and Formic Acid
• Reaction of N-Haloamide. XVI. Reaction of N, N-Dichlorophenylacetamide with Aliphatic Secondary Amines
• Reaction of N-Haloamide. XIV. Reaction of N, N-Dichlorophenylacetamide with Cyclohexene
• Reaction of N-Haloamide. XVII. Bromo-formyloxylation of Olefins with N, N-Dibromobenzenesulfonamide and Formic Acid
• Reaction of N-Haloamide. XIII. The Coupled Reaction of N, N-Dibromobenzenesulfonamide and Formamide or Dimethylformamide with Cyclohexene
• Reaction of N-Haloamide. XI. Reaction of N, N-Dichlorobenzenesulfonamide and N, N-Dichlorobenzamide with Dihydropyran
• Reaction of N-Haloamide. X. Reaction of N, N-Dichlorobenzamide with Cyclohexene
• Studies on Benzhydryl Derivatives. I. Synthesis and Anti-Inflammatory Activity
• Chemical Studies on Antibiotics produced by Actinomycetes. VII. Racemomycin. (4). On Racemomycin-O (i)
• Isomerization between trans-2-Benzenesulfonamido-3-bromotetrahydropyran and Its Isomer
• Reaction of N-Halosulfonamide. VI. Reaction of N-Bromobenzenesulfonamides with Dihydropyran. (2)
• Reaction of N-Halosulfonamide. V. Reaction of N, N-Dibromobenzenesulfonamide with Dihydropyran. (1)
• (250) トマトでのTMVの増殖に対するサルチル酸およびアントラニル酸のベンズヒドリル誘導体の影響 (昭和55年度日本植物病理学会大会講演要旨)
• Reaction of N-Haloamide. VII. A Cleavage Reaction of Ether with N, N-Dihalobenzenesulfonamide. (2). Reactions of Tetrahydrofuran with N, N-Dibromobenzenesulfonamide, N-Bromosuccinimide, or Bromine. (1)
• Chemical Studies on Antibiotics produced by Actinomycetes. X. Racemomycin (7). Structure of Racemomycin-O
• Chemical Studies on Antibiotics produced by Actinomycetes. IX. Racemomycin. (6). Structure of New Degradation Product of Recemomycin-O
• Racemomycin (5). Degradation Products of Racemomycin-O.

もっと見る 閉じる

スポンサーリンク