降圧剤を目的としたBenzhydrylidene Guanidine類の合成と活性(II 予防および治療)(A 基礎的研究)

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概要

• 論文の詳細を見る

• On the basis that benzhydryl groups appear in the various medicines in high probability, a series of benzhydryl derivatives of guanidines was synthesized. Molecular coordinate analysis was applied on the known antihypertensive drugs having guanidine moieties and a common conformation was found. The designed compound well matched with this conformation. It was expected that the activity of them might provide an information on the drug-receptor interaction. The rough screening test of the synthetic intermediates and products showed no activity for hypertension but some of them exhibited weak effects for anticholinergic, antihistaminic, muscle relaxation, etc.

• 近畿大学の論文
• 1981-09-25

著者

• 竹村 庄司

  Faculty Of Pharmaceutical Sciences Kinki University

• 竹村 庄司

  近畿大学薬学部医薬品化学教室

• 三木 康義

  近畿大学薬学部医薬品化学教室

• 三木 康義

  近畿大学 薬学部

• 竹村 庄司

  Faculty of Pharmaceutical Sciences, Kinki University

• 三木 康義

  近畿大学薬学部

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