THE ICHTHYOTOXICITY AND CORONARY VASODILATOR ACTION OF 3,3'-DIHYDROXY-α,β-DIETHYLSTILBENE(Communications to the Editor)

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概要

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• Like diethylstilbestrol (II), 3,3'-dihydroxy-α,β-diethyl-stilbene (I), an isomer of II, had strong ichthyotoxicity and coronary vasodilator action on the isolated guinea-pig heart. The median tolerance limit (TLm) at 48 h was 3.00 ppm in Orysios latipes and 3.20 pprn in Carassius auratus. The ichthyotoxic activity of I was stronger than that of II. The vasodilator activity of I in the isolated guinea-pig heart (ED_<50>: 4.30 μg/ heart) was weaker than that of II (ED_<50> : 0.26 μg/heart) . However, the action of I was stronger than that of papaverine (ED_<50> : 7.0 μg/heart) , used as a standard. On the other hand, I, unlike II and other oxystilbene derivatives so far examined, had a cardiotonic effect. In this respect, the effect of I on the isolated guinea-pig heart is noteworthy. Owing to its negligible hormonal side effect, the above-mentioned activities of I are of considerable interest.

• 社団法人日本薬学会の論文
• 1987-02-25

著者

• 竹村 庄司

  Faculty Of Pharmaceutical Sciences Kinki University

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 小川 雅史

  Osaka University Of Pharmaceutical Sciences

• 三木 康義

  Faculty of Pharmaceutical Sciences, Kinki University

• 久保 真百合

  Osaka University of Pharmaceutical Sciences

• 斉藤 喜宜

  Faculty of Phrmaceutical Sciences, Kinki University

• 辻坊 裕

  大阪薬大

• 三木 康義

  Faculty Of Pharmaceutical Sciences Kinki University

• 斉藤 喜宜

  Faculty Of Phrmaceutical Sciences Kinki University

• 三木 康義

  近畿大学 薬学部

• 竹村 庄司

  Faculty of Pharmaceutical Sciences, Kinki University

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