Biological Activities of Racemomycin-B, β-Lysine Rich Streptothricin Antibiotic, the Main Component of Streptomyces lavendulae OP-2
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概要
- 論文の詳細を見る
Racemomycin-B (RM-B), the main component of Streptomyces lavendulae OP-2 which is the basis of 50% of the antibiotics produced, is a streptothricin antibiotic which contains three β-lysine moieties in the molecule. RM-B had antimicrobial activity against plant-pathogenic microorganisms and growth-inhibitory activity against the root of Brassica rapa L. at the concentration of 50 ppm. It strongly inhibited the growth of Pseudomonas syringae pv. tabaci IFO-3508 (minimum inhibitory concentration (MIC) : 0.4 μg/ml), and also showed antifungal activity against six kinds of Fusarium oxysporum species (MIC : 0.1-2.0 μg/ml). The antimicrobial activity of RM-B was much stronger than those of RM-A and -C which contain, respectively, one and two β-lysine moieties in their molecules. The above activities of RM-A, -C and -B were thus in the order of -B>-C>-A : namely, the biological activity of racemomycin compounds tended to be stronger with increase in number of β-lysine moieties in the molecule.
- 公益社団法人日本薬学会の論文
- 1990-08-25
著者
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山口 智美
Osaka University Of Pharmaceutical Sciences
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稲森 善彦
Osaka University of Pharmaceutical Sciences
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辻坊 裕
Osaka University of Pharmaceutical Sciences
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網野 比佐子
Osaka University of Pharmaceutical Sciences
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坪井 万里子
Osaka University of Pharmaceutical Sciences
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辻坊 裕
大阪薬大
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