Relationship between Structure and Phytogrowth-Inhibitory Activity of 2,5-Dihydroxy-1,4-dithiane-Related Compounds

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概要

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• Ten derivatives (II-VI and VIII-XII) from 2,5-dihydroxy-1,4-dithiane (I) and 2,5-dihydroxy-2,5-dimethyl-1,4-dithiane (VII) showed inhibitory activity against the growth of root of Brassica rapa L. The inhibitory activity of all ten derivatives was higher than that of the original compounds I and VII. In particular, VIII-XII inhibited the germination of this plant at the concentration of 1.0×10^<-3>M. Among the derivatives VIII-XII, IX exhibited the strongest inhibition. Compound III had the most potent inhibitory activity among the derivatives II-VI. The results indicate that acylation of hydroxyl group with propionic acid enhances the activity. The inhibitory effect of VIII-XII was much stronger than that of II-VI. The findings suggest that methyl groups at 2,5 dipositions play an important role in the inhibitory activity of 2,5-dihydrosy-1,4-dithiane-related compounds. In both derivatives II-VI and VIII-XII, the inhibitory effect of the substituent was in the order of propionyl > acetyl > butyryl > valeryl > isobutyryl. All radicles of this plant treated with the compounds I-XII showed negative geotropism.

• 社団法人日本薬学会の論文
• 1992-02-25

著者

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 馬場 きみ江

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 室 親明

  Osaka University Of Pharmaceutical Science Nasahara

• 宮本 勝城

  Osaka University of Pharmaceutical Sciences

• 大石 宏文

  Osaka University of Pharmaceutical Sciences

• 宮本 勝城

  大阪薬大・微生物

• 辻坊 裕

  大阪薬大・微生物

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