Biological Actions of the Natural Coumarins. I. Changes of Lipids and Glucose Levels in Rat Plasma after Intraperitoneal Administration of Various Linear-Type Furanocoumarins

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概要

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• Experiments were carried out on the effects of various linear-type furanocoumarins on the concentrations of lipids and glucose in rat plasma. It was found that bergapten and xanthotoxin cause hypolipidemia. In contrast, imperatorin, isoimperatorin, oxypeucedanin and oxypeucedanin hydrate cause hyperlipidemia. However, no effect on any lipid fraction in rat plasma was produced by isopimpinellin, phellopterin, ferulin, byakangelicin or sec-O-acetylbyakangelicin. Glucose level in rat plasma was increased by isopimpinellin and psoralen, and decreased by oxypeucedanin. These results suggest that the effects of linear-type furanocoumarins on lipid concentration in rat plasma depend upon whether substitution is present or not at the 5- and 8-positions of the skeleton and upon the kinds of substituents.

• 公益社団法人日本薬学会の論文
• 1984-11-25

著者

• 馬場 きみ江

  Osaka University of Pharmaceutical Sciences

• 小澤 貢

  Osaka University of Pharmaceutical Sciences

• 安田 正秀

  大阪薬科大学

• 安田 正秀

  Osaka College of Pharmacy

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