Liver and Plasma Lipids in Vitamin E-Deficient Rats

概要

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To investigate metabolic alterations during vitamin E-deficiency, the content of lipid peroxides and lipids in liver and plasma was determined using vitamin E-deficient rats, and its results were as follows : Lipid peroxide in the liver from vitamin E-deficient rats increased about 3 times over the control group, and the value returned to the normal level after intraperitoneal administration of vitamin E in a dose of 50mg/kg/day for 6 days, but that in plasma was almost constant. In vitamin E-deficiency, C_<16 : 1>, C_<18 : 1>, and C_<20 : 4> increased mainly in triglycerides (TG) in liver lipids. C_<18 : 2> decreased in the fractions of phospholipids but not in TG fraction. On the other hand, in plasma from vitamin E-deficient rats, C_<18 : 1> increased and C_<18 : 2> decreased in all the fractions of lipids. Decrease of C_<20 : 4> was found in phosphatidylethanolamine (PE) and phosphatidylcholine (PC) in plasma lipids. Free fatty acids of plasma in vitamin E-deficiency increased by approx. 76%, and TG content increased about 73% in the liver and 35% in the plasma. The total cholesterol content of the liver and plasma from vitamin E-deficient rats increased about 55 and 20%, respectively. The content of phospholipids in the liver and plasma showed little change in vitamin E-deficiency.
公益社団法人日本薬学会の論文
1979-02-25