ビタミンE欠乏時におけるラット肝Subcellular Organelleの脂質成分にいて

概要

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1) An in vivo study was made to obtain quantitative data on the fatty acid composition of mitochondria, microsomes, and supernatant fraction (105000×g) of livers from rats fed a diet deficient in vitamin E. 2) Difference in the fatty acid composition was observed in subcellu1ar fraction of liver from control and vitamin E-deficient rats. 3) In the fractions of liver from vitamin E-deficient rats, palmitooleic acid and oleic acid increased, but linoleic acid, arachidonic acid, and docosahexaenoic acid decreased. 4) Fatty acid composition of mitochondria and microsomes of liver from vitamin E-deficient rats were recovered by treatment with α-tocopherol (100 mg/kg/day, for five days). 5) Tinoridine has the same effect as α-tocopherol on the fatty acid composition in the microsomes and supernatant fraction of liver from vitamin E-deficient animals.
社団法人日本薬学会の論文
1974-01-25