ラット肝ミトコンドリアにおける脂質過酸化物の形成(第1報)

概要

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1) In vitro experiment was made to clarify the interrelationship among lipid peroxidation, lipid compositions, and cytochrome oxidase activity in rat liver mitochondria. 2) Ascorbic acid and metal ions (Fe^<2+>, Fe^<3+>, Cu^<2+>) catalysed lipid peroxidation in mitochondria, but Ca^<2+> inhibited it. 3) Combined application of ascorbic acid with Fe^<2+> (or Fe^<3+>) markedly, increased the formation of lipid peroxide in mitochondria but that of ascorbic acid with Ca^<2+> or Cu^<2+> did not. 4) Linoleic acid and LAHPO did not affect the peroxidation process in liver mitochondria, in vivo or in vitro. 5) Lipid peroxidation in vitro promoted by ascorbic acid and Fe^<2+> was accompanied by the decrease of cytochrome oxidase activity and unsaturated fatty acid (C_<18 : 2>, C_<20 : 4>, C_<22 : 6>) content of mitochondria. Among the fatty acid compositions of phosphatidylserine and phosphatidylinositol, diminution of linoleic acid and arachidonic acid was predominant. 6) Relationship among lipid compositions, lipid peroxidation, and cytochrome oxidase activity in rat liver mitochndria was discussed.
公益社団法人日本薬学会の論文
1972-03-25