ラット肝, 血漿中の脂質含量に対するビタミンEの影響

概要

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To examine the effect of vitamin E on plasma and liver lipid content and on the growth of rats, vitamin E (0.1,1.0,10,or 50 mg/kg) was injected intraperitoneally once a day for one month. Weight gain in vitamin E-injected rats showed a tendency to decrease in comparison to control animals, however, the liver body/weight ratios were not altered. Fatty acid composition in total rat liver and plasma lipids was not affected by the administration of vitamin E. Vitamin E administration effected no changes in free fatty acid and total cholesterol concentration in the liver and plasma. On the other hand, triglyceride contents in the liver decreased in proportion to the doses of vitamin E, namely the reduction was about 25% and 35% by the administration of vitamin E in a dose of 10 and 50 mg/kg/day for one month, respectively. Concentration of plasma triglycerides increased by the administration of Tween 80 (4 mg/kg/day, for one month), however the increased triglycerides decreased and recovered to the control levels by the treatment with vitamin E (50 mg/kg/day). The present results suggest that vitamin E may have a lowering effect on triglycerides in the rat liver.
公益社団法人日本薬学会の論文
1979-03-25