The Biological Activities of Podophyllotoxin Compounds

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概要

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• Podophyllotoxin (I), like deoxypodophyllotoxin (II), showed various biological activities. First, I had ichthyotoxic activity : the median tolerance limit at 48 h was 0.73 ppm in Oryzias latipes and 1.20 ppm in Carassius auratus. Second, I showed inhibitory activities on the growth of two plant species at a concentration of 50 ppm. Third, I showed insecticidal activities against all insects examined except for Spodoptera litura. A rather strong insecticidal activity toward Epilachna sparsa orientalis larvae was found, with mortality of 95% at 20 ppm. Futhermore, I and II had marked antitumor activities against L 5178 Y mouse leukemic cells in vitro [ID_<50> (μg/ml) : II, 0.0047 and I, 0.0054].

• 社団法人日本薬学会の論文
• 1986-09-25

著者

• 小澤 貢

  大阪薬大

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 馬場 きみ江

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 小澤 貢

  Osaka University of Pharmaceutical Sciences

• 小川 雅史

  Osaka University Of Pharmaceutical Sciences

• 久保 真百合

  Osaka University of Pharmaceutical Sciences

• 藤田 榮一

  Osaka University of Pharmaceutical Sciences

• 藤田 栄一

  京都大学化学研究所

• 藤田 栄一

  Osaka University Of Pharmaceutical Sciences

• 辻坊 裕

  大阪薬大

• 藤田 榮一

  大阪薬科大学

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