Novel Hypotensive Peptides from the Body of Elaphe climacophora

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概要

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• Four hypotensive peptides called elapherine-A, -B, -C and -D were isolated from the body of Elaphe climacophora after removal of the internal organs. Elapherine-A, which had the lowest molecular weight, exhibited a prolonged fall for 5 min in the blood pressure of spontaneously hypertensive rats, wherase elapherin-B, -C and -D displayed a transient fall in the blood pressure. The molecular weights of elapherine-A--D estimated from sodium dodecyl sulfate (SDS) gel disk electrophoresis were 6600,6900,7000 and 7200,respectively. The isoelectric points of these peptides were 10.4,10.6,10.7 and 10.5,respectively. They possessed a single polypeptide chain of 34-35 (elapherine-A), 56-58 (elapherine-B), 56-57 (elapherine-C) and 52-53 (elapherine-D) amino acid residues.

• 社団法人日本薬学会の論文
• 1990-04-25

著者

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 佐藤 浩史

  Osaka University Of Pharamaceutical Sciences

• 谷口 暢

  Osaka University, of Pharamaceutical Sciences

• 釜谷 好美

  Suntory Institute for Bioorganic Research

• KENNY Peter

  Suntory Institute for Bioorganic Research

• 野本 享資

  Suntory Institute for Bioorganic Research

• 辻坊 裕

  大阪薬大

• 谷口 暢

  Osaka University Of Pharamaceutical Sciences

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