81 紅藻類ハナヤナギから単離された殺虫活性物質の構造

概要

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We have reexamined the constituents of a red alga, Chondria armata, and fractionated water extracts by means of the assay based on insecticidal activity against American cockroach. From the fraction exhibiting insecticidal activity, we have isolated seven novel amino acids, isodomoic acid-A (III), -B (IV), -C (V), -D (VII), nordomoic acid (VI), domoilactone-A (VIII), and domoilactone-B (IX), and two palytoxin analogs, CA-I and CA-II. Their structures were elucidated on the basis of their spectral data (Table I, II, and III). Domoic acid (I) induced significant contraction of the hindgut excised from American cockroach. This result indicated that the site of action may be the neuromuscular junction. Domoic acid (I), its related compounds (III - VII), and palytoxin analogs (CA-I and CA-II) showed strong insecticidal activity against American cockroach (Table IV).
天然有機化合物討論会の論文
1985-09-07