Cytotoxic Effect of Hinokitiol and Tropolone on the Growth of Mammalian Cells and on Blastogenesis of Mouse Splenic T Cells

スポンサーリンク

概要

• 論文の詳細を見る

• Hinokitiol (I) and tropolone (II) showed characteristic cytotoxic effects in vitro on five kinds of human and murine cell lines and blastic lymphocytes from mouse splenocytes. The cytotoxic effect of I on the growth of murine and human tumor cell lines, including RL♂-1,MH134,HL60,K562 and KATO-III was definite when examined by thymidine incorporation into DNA and its 50% inhibitory concentration (IC_<50>) on all cells was 0.3-0.6 μg/ml. Compound II also showed comparable cytotoxic effects on these cell lines, indicating a little lower activity when compared to I. Furthermore, I and II also completely suppressed the [^3H]thymidine ([^3H]TdR) incorporation of mitogen-induced blastic lymphocytes. The suppressive activity on mouse lymphocyte proliferative response to concanavaline-A was also found with both compounds at a low concentration of 0.32 μg/ml. As compound I is known to be of fairly low toxicity (LD_<50> : 453+24 mg/kg in mice), the antitumor and immuno-suppressive effect of hinokitiol (I) should be further investigated.

• 社団法人日本薬学会の論文
• 1993-05-15

著者

• 水柿 道直

  Department of Pharmaceutical Science, Tohoku University Hospital

• 稲森 善彦

  Osaka University of Pharmaceutical Sciences

• 辻坊 裕

  Osaka University of Pharmaceutical Sciences

• 大石 宏文

  Osaka University of Pharmaceutical Sciences

• 麻生 久

  Department Of Animal Products National Institute Of Animal Industry

• 石田 名香雄

  仙台微生物研究所

• 石田 名香雄

  The Sendai Institute of Microbiology

• 水柿 道直

  Department Of Pharmaceutical Science Tohoku University Hospital

• 辻坊 裕

  大阪薬大

• 石井 二三夫

  Department of Pharmaceutical Sciences, Tohoku University Hospital

• 石井 二三夫

  Department Of Pharmaceutical Sciences Tohoku University Hospital

関連論文

• P-67 院内製剤リファジン液の品質管理
• Phenylephrine 軟膏の製剤学的特性の評価 : 軟膏調製における安定性に関する検討
• FEASIBILITY OF USING [^O_2]11-DEHYDROTHROMBOXANE B_2 AS AN INTERNAL STANDARD OF IMMUNOAFFINITY PURIFICATION FOLLOWED BY GAS CHROMATOGRAPHY/SELECTED ION MONITORING
• Dimethylisopropylsilyl Ether Derivative in Gas Chromatography/Mass Spectrometry of 11-Dehydrothromboxane B_2. II. : Fragmentatin of Methyl Ester-11-n-propylamide-dimethylisopropylsilyl Ether Derivative
• DIMETHYLISOPROPYLSILYL ETHER DERIVATIVE IN GAS CHROMATOGRAPHY/MASS SPECTROMETRY OF 2,3-DINOR-6-KETO-PROSTAGLANDIN F
• Antibacterial Activity of Two Chalcones, Xanthoangelol and 4-Hydroxyderricin, Isolated from the Root of Angelica keiskei KOIDZUMI
• 30-P3-20 医師-薬剤師の情報交換と薬学管理料算定に関する意識・実態調査 : せんだい医薬連携セミナー 保険薬局対象アンケート調査(地域連携・薬薬連携・その他,社会の期待に応える医療薬学を)
• P-222 成分の化学的安定性に基づく長期投与対策
• Real-Time Multiplex PCR/Melting Curve Analysisを用いたミトコンドリアDNA A1555G変異の簡易迅速検出
• P-402 薬品の安全管理における薬剤師の活動 (2) : コンピュータオーダリングにおける「4 文字必須入力」の導入
• P-401 薬品の安全管理における薬剤師の活動 (1) : 病棟における薬品管理体制の確立
• 25-P7-50 患者の退院後の生活様式を考慮した薬剤管理指導の実践
• 13P-5-05 白血病治療時の抗悪性腫瘍薬による口内炎予防法の検討
• 服薬コンプライアンス尺度(第2報) : 心療内科における服薬コンプライアンスに関わる諸要因
• 服薬コンプライアンス尺度(第1報) : 服薬コンプライアンス尺度の作成
• Synthesis of ^C-Labeled Imipramine and Its Biodistribution in Mice : A Potential Tracer for Positorn Emission Tomography
• 藻類およびコケ培養細胞に対する rhodanine と 2(5H)-thiophenone の効果
• Phytogrowth-Inhibitory Activities of 2-Thiophenecarboxylic Acid and Its Related Compounds
• Phytogrowth-Inhibitory Activities of Sulfur-Containing Compounds. II.The Inhibitory Activities of Thiosalicylic Acid and Dihydro-2(3H)-thiophenone-Related Compounds on Plant Growth
• Phytogrowth-Inhibitory Activity of Sulphur-Containing Compounds. I. Inhibitory Activities of Thiazolidine Derivatives on Plant Growth
• Relationship between Structure and Phytogrowth-Inhibitory Activity of 2,5-Dihydroxy-1,4-dithiane-Related Compounds
• 521 抗メチル化ヌクレオサイドモノクローナル抗体を用いた食道癌の免疫組織化学的検討(第32回日本消化器外科学会総会)
• Structure-Activity Relationship of 3,3'-Dihydroxy-α, β-diethyldiphenylethane and Its Related Compounds
• Inhibitory Effects of 3,3', 4,5'-Tetrahydroxystilbene and 3,3', 4,5'-Tetrahydroxybibenzyl, the Constituents of Cassia garrettiana on Antigen-Induced Histamine Release in Vitro
• THE INHIBITORY EFFECT OF 3,3', 4,5'-TETRAHYDROXYSTILBENE, A CONSTITUENT OF CASSIA GARRETTIANA, ON ANTI-IgE-INDUCED HISTAMINE RELEASE FROM HUMAN BASOPHILS IN VITRO
• Phytogrowth-Inhibitory and Antimicrobial Activities of 3,4'-Dihydroxy-α, β-diethylstilbene, the Isomer of Diethylstilbestrol
• Hypotensive Effects on Spontaneously Hypertensive Rats and Antifungal Activity on Various Species of Fusarium oxysporum of Diethylstilbestrol-Related Compounds
• The Hypotensive Effect and Antifungal Activity of 3,3'-Dihydroxy-α, β-diethyldiphenylethane
• Antifungal Activity against Plant-Pathogenic Fungi and Phytogrowth-Inhibitory Activity of 3,3'-Dihydroxy-α, β-diethyldiphenylethane
• Biological Actibities of Hexesterol
• THE ICHTHYOTOXICITY AND CORONARY VASODILATOR ACTION OF 3,3'-DIHYDROXY-α,β-DIETHYLSTILBENE(Communications to the Editor)
• The Biological Activities of Podophyllotoxin Compounds
• The Biological Activities of Diethylstilbestrol and Its Derivatives
• THE ICHTHYOTOXICITY AND CORONARY VASODILATOR ACTION OF DIETHYLSTILBESTROL
• 25-A7-45 薬剤師による手術部の薬品管理 : 導入経緯とその成果
• Novel Hypotensive Peptides from the Body of Elaphe climacophora
• Antimicrobial Activity on Plant-Pathogenic Microorganisms and Phytogrowth-Inhibitory Activity of Streptothricin Antibiotics, Racemomycin-A and -C
• P-105 ステロイドの副作用に予防投与は必要か? : 消化性潰瘍
• 医薬品による排泄物(尿・便)の着色に関する情報の評価
• 25-P7-49 服薬指導患者における健康食品の利用状況と問題点
• P-223 医薬品情報の評価 (3) : 横紋筋融解症に関する副作用情報の問題点
• P-235 外科領域における入院癌患者に対する薬剤管理指導業務の一考察《患者の訴えに対する病棟薬剤師の役割》
• P-66 薬剤管理指導業務効率化への取り組み
• モノテルペンの生物学的特性 モノテルペンのラットに対する血圧降下作用と植物病原真菌に対する抗真菌効果
• 細菌学イン仙台
• Phytogrowth-Inhibitory Activities of Tropolone and Hinokitiol
• Extra-Weak Chemiluminescence of Drugs. IX. : Extra-Weak Chemiluminescene of Neocarzinostatin Injection
• Extra-weak Chemiluminescence of Drugs. VII. : A Possible Pathway of Chemiluminescence Generation from Imipramine Hydrochloride Produced by Autoxidation
• Extra-Weak Chemiluminescence of Drugs. V. The Extra-Weak Chemiluminescence of Imipramine Hydrochloride Produced by Autoxidation(Pharmaceutical)
• EXTRA-WEAK CHEMILUMINESCENCE OF DRUGS. II. RELATIONSHIP BETWEEN THE STRUCTURE AND THE EXTRA-WEAK CHEMILUMINESCENCE OF ORGANIC COMPOUNDS
• Characterization of Secondary Structure of Neocarzinostain Apoprotein
• マススペクトロメトリーの裁判化学領域への応用(第2報)アヘンアルカロイドの定量
• Synthetic Anthracyclines : Total Synthesis of D-Ring Pyridine and Pyrazine Analogues of 11-Deoxydaunomycin
• Neocarzinostatin : Selective Tryptophan Oxidation and Neocarzinostatin-Chromophore Binding to Apo-Neocarzinostatin
• NEOCARZINOSTATIN : CARBOXYL-TERMINAL-43-PEPTIDE RESIDUE OF APO-NEOCARZINOSTATIN AS THE BINDING SITE OF NEOCARZINOSTATIN-CHROMOPHORE(Communications to the Editor)
• 48 抗腫瘍性抗生物質ネオカルチノスタチン・クロモフォアの化学構造
• 抗腫瘍性抗生物質ネオカルチノスタチンクロモフォアの化学構造(化学の窓)
• B-15 向精神薬の体内動態と作用発現に関する研究 VII : ポジトロン標識コカインのマウス脳内動態の検討
• 39 向精神薬の体内動態と作用発現に関する研究 V : ポジトロン標識メタンフェタミンの動態と依存症との関連性について
• Further Studies on the Reaction of Guanosine Derivatives with Phosphorus Trichloride
• Determination of β-Lactam Antibiotics in Water by Fluorescence Quenching of Mercurochrome, and Application for Simple Investigation of Potency
• Study on Conformations-Biological Activities Relationships for Podophyllotoxin Analogues Based on Crystal Structure of Deoxypodophyllotoxin (Anthricin)
• Studies on the Constituents of the Water Extract of the Root of Mulberry Tree (Morus bombycis KOIDZ)
• Conformational Studies of Semotiadil (SD-3211), a Novel Ca^ Antagonist
• Molecular Dynamics Simulation of Papain-E-64 (N-[N-(L-3-trans-Carboxyoxirane-2-carbonyl)-L-leucyl]agmatine) Complex
• The Biological Actions of Deoxypodophyllotoxin (Anthricin). I. Physiological Activities and Conformational Analysis of Deoxypodophyllotoxin
• 担癌マウスモデルを用いた血清中1-メチルアデノシンとシュードウリジンの腫瘍マーカーへの応用性の検討
• Cytotoxic Effect of Hinokitiol and Tropolone on the Growth of Mammalian Cells and on Blastogenesis of Mouse Splenic T Cells
• Isolation of Cytotoxic Substance, Kalafungin from an Alkalophilic Actinomycete, Nocardiopsis dassonvillei subsp. presina
• Effects of 3,3'-dihydroxy-α, β-diethylstilbene and 3,3', 4,5'-Tetrahydroxystilbene on Microtubule Assembly in Vitro, Aneuploidy Induction, and Cellular Microtubule and Actin Networks
• Toxicological Approaches to Streptothricin Antibiotics. IV. Toxicity of Streptothricin Antibiotics to the Blood
• Excellent Chiral Induction by Diene Iron-Tricarbonyl Moiety. I : Diastereoselective [4+2] Type Cycloaddition of 1-Azatriene Iron-Tricarbonyl Complex
• Changes of Tissue Histopathology and Uric Acid Excretion in Silkworm Larvae Intoxicated with Deoxypodophyllotoxin and Racemomycin-D, and during Starvation
• Mechanisms of Inhibitory Action of Racemomycin-D on Plant Growth
• The Biological Activities of 3,4-O-Isopropylidene-3,3'4,5'-tetrahydroxystilbene
• Mechanisms of Insecticidal Action of Deoxypodophyllotoxin (Anthricin). II. Histopathological Studies on Tissues of Silkworm Larvae Intoxicated by Deoxypodophyllotoxin
• THE ANTIFUNGAL ACTIVITY OF STILBENE DERIVATIVE
• Physiological Activities of 3,3', 4,5'-Tetrahydroxystilbene Isolated from the Heartwood of Cassia garrettiana CRAIB.
• The Mechanisms of Delayed Insecticidal Action of Streptothricin Antibiotics. I. Toxic Symptoms and Distribution of Racemomycin-D into the Tissues of the 5th Instar Larvae of Silkworm, Bombyx mori LINNE
• The Mechanisms of Delayed Insecticidal Action of Streptothricin Antibiotics. II. Effect of Racemomycin-D on Excretion Function of the 5th Instar Larvae of Silkworm, Bombyx mori LINNE
• Insecticidal Activity of Streptothricin Antibiotics
• Biological Activities of Racemomycin-B, β-Lysine Rich Streptothricin Antibiotic, the Main Component of Streptomyces lavendulae OP-2
• Meisenheimer Rearrangement of Azetopyridoindoles. VII. Ring Expansion of 2-Phenylhexahydroazeto[1', 2' : 1,2]pyrido[3,4-b]indoles by Oxidation with m-Chloroperbenzoic Acid
• [3,3]Sigmatropic Ring Expansion of Cyclic Thionocarbonates. VII. On the Formation of 8-Membered Thionocarbonates as the Intermediates
• [3,3]Sigmatropic Ring Expansion of Cyclic Thionocarbonates. VI. Regioselective Wohl-Ziegler Bromination of 10-Membered Thiolcarbonates
• Photocyclization of Enamides. XXXVI. Alkaloid Synthesis Using Furopyridone as a Synthon : Synthesis of Key Intermediates for the Synthesis of Eburnamine-Vincamine Alkaloids
• Chemistry of Tetrahydro-1,3-oxazin-2-one : New Method for the Synthesis of Indoloquinolizidine Derivatives
• MEISENHEIMER REARRANGEMENT OF 2-ETHENYL-1,4,5,10b-TETRAHYDRO-2H-AZETOPYRIDO[3,4-b__-]INDOLE N-OXIDES : NEW ROUTE TO THE 12(S)CARBA-EUDISTOMIN SKELETON
• Phytogrowth-Inhibitory and Antibacterial Activities of 2,5-Dihydroxy-1,4-dithiane and Its Derivatives
• EFFECT OF 3,3'-DIHYDROXY-α, β-DIETHYLDIPHENYLETHANE ON CORONARY AND MESENTERIC ARTERIES ISOLATED FROM GUINEA-PIGS
• Stability of Enzyme Preparations on Radiosterilization
• A Novel Laccase Inhibitor, N-Hydroxyglycine, Produced by Penicillium citrinum YH-31
• Biosynthesis of Streptothricin Antibiotics. III. Incorporation of D-Glucosamine into D-Gulosamine Moiety of Racemomycin-A
• Hypotensive Compounds Isolated from Alcohol Extract of the Unossified Horn of Cervus elaphus L. var. xanthopygus MILNE-EDWARG (Rokujo). I. Isolation of Lysophosphatidyl Choline as a Hypotensive Principle and Structure-Activity Study of Related Compounds(P
• CHEMICAL STRUCTURE OF A NEW METABOLITE ISOLATED FROM THE MYCELIUM OF ASPERGILLUS TERREUS VAR. AUREUS
• Mechanism of Insecticidal Action of Deoxypodophyllotoxin(Anthricin). III. : The Mode of Delayed Insecticidal Action of Deoxypodophyllotoxin
• The Mechanisms of Delayed Insecticidal Action of Streptothricin Antibiotics. III. The Mode of Delayed Insecticidal Action of Racemomycin-A(Biological)
• Synthesis of (±)-trans- or cis-(5-Aminomethyltetrahydrofuranyl)imidazole by Mitsunobu Cyclization : Synthetic Studies toward Novel Histamine H_3 or H_4-Ligands
• Efficient and β-Stereoselective Synthesis of 4(5)-Methyl-5(4)-(5-amino-5-deoxy-β-D-ribofuranosyl)imidazole and Related Compounds Exhibiting Antiulcer Activity
• Meisenheimer Rearrangement of Azetopyridoindoles. VIII. Synthesis and Antiviral Activities of 12-Carbaeudistomin Analogs

もっと見る 閉じる

スポンサーリンク