Meisenheimer Rearrangement of Azetopyridoindoles. VIII. Synthesis and Antiviral Activities of 12-Carbaeudistomin Analogs

スポンサーリンク

概要

• 論文の詳細を見る

• Eudistomins, isolated from the colonial tunicate Eudistoma olivaceum, have been a synthetic target due to their strong antiviral activity against Herpes simplesx virus (HSV-1) and activities against certain types of tumors in vivo. In order to examine the structure-activity relationship of eudistomins, 12-carbaeudistomin analogs were synthesized and their activities against influenza A and B virus, HSV-1,HSV-2 and human cytomegalovirus were investigated. Among them, racemic 6-methoxy-12-carbaeudistomin showed similar activity to (-)-debromoeudistomin K, synthesized as a control compound.

• 公益社団法人日本薬学会の論文
• 1996-05-15

著者

• 大石 宏文

  Osaka University of Pharmaceutical Sciences

• OHISHI Hirofumi

  Osaka University of Pharmaceutical Sciences

• Ohishi H

  Osaka University Of Pharmaceutical Sciences

• Kimura Tetsuya

  Osaka University Of Pharmaceutical Sciences

• Suzutani Tatsuo

  Department Of Microbiology Fukushima Medical University

• Azuma Masanobu

  Asahikawa Medical College Department Of Microbiology

• Kurihara T

  Osaka University Of Pharmaceutical Sciences

• Ohishi H

  Osaka Univ. Pharmaceutical Sci. Osaka Jpn

• 米田 龍司

  Agroscience Research Laboratories Sankyo Co. Ltd.

• HARUSAWA Shinya

  Osaka University of Pharmaceutical Sciences

• SAKAMOTO Yasuhiko

  Osaka University of Pharmaceutical Sciences

• YONEDA Ryuji

  Osaka University of Pharmaceutical Sciences

• KURIHARA Takushi

  Osaka University of Pharmaceutical Sciences

• SUZUTANI Tatsuo

  Asahikawa Medical College, Department of Microbiology

• Sakamoto Y

  Alfresa Pharma Co.

関連論文

• Relationship between Structure and Phytogrowth-Inhibitory Activity of 2,5-Dihydroxy-1,4-dithiane-Related Compounds
• Structure-Activity Relationship of 3,3'-Dihydroxy-α, β-diethyldiphenylethane and Its Related Compounds
• Synthetic Anthracyclines : Total Synthesis of D-Ring Pyridine and Pyrazine Analogues of 11-Deoxydaunomycin
• Further Studies on the Reaction of Guanosine Derivatives with Phosphorus Trichloride
• Study on Conformations-Biological Activities Relationships for Podophyllotoxin Analogues Based on Crystal Structure of Deoxypodophyllotoxin (Anthricin)
• Thermal Elimination of Carbonyl Sulfide from O-Aryl Thionocarbonates of Pyrrolidine-, Piperidine-, and Tetrahydrothiophene-2-ethanol
• Novel Transformation of Azabicyclothionocarbonate to Azaspirolactone
• Conformational Studies of Semotiadil (SD-3211), a Novel Ca^ Antagonist
• Molecular Dynamics Simulation of Papain-E-64 (N-[N-(L-3-trans-Carboxyoxirane-2-carbonyl)-L-leucyl]agmatine) Complex
• Cytotoxic Effect of Hinokitiol and Tropolone on the Growth of Mammalian Cells and on Blastogenesis of Mouse Splenic T Cells
• Synthesis of Novel 4(5)-(5-Aminotetrahydropyran-2-yl)imidazole Derivatives and Their in Vivo Release of Neuronal Histamine Measured by Brain Microdialysis
• Excellent Chiral Induction by Diene Iron-Tricarbonyl Moiety. I : Diastereoselective [4+2] Type Cycloaddition of 1-Azatriene Iron-Tricarbonyl Complex
• Meisenheimer Rearrangement of Azetopyridoindoles. VII. Ring Expansion of 2-Phenylhexahydroazeto[1', 2' : 1,2]pyrido[3,4-b]indoles by Oxidation with m-Chloroperbenzoic Acid
• [3,3]Sigmatropic Ring Expansion of Cyclic Thionocarbonates. VII. On the Formation of 8-Membered Thionocarbonates as the Intermediates
• [3,3]Sigmatropic Ring Expansion of Cyclic Thionocarbonates. VI. Regioselective Wohl-Ziegler Bromination of 10-Membered Thiolcarbonates
• Photocyclization of Enamides. XXXVI. Alkaloid Synthesis Using Furopyridone as a Synthon : Synthesis of Key Intermediates for the Synthesis of Eburnamine-Vincamine Alkaloids
• Chemistry of Tetrahydro-1,3-oxazin-2-one : New Method for the Synthesis of Indoloquinolizidine Derivatives
• MEISENHEIMER REARRANGEMENT OF 2-ETHENYL-1,4,5,10b-TETRAHYDRO-2H-AZETOPYRIDO[3,4-b__-]INDOLE N-OXIDES : NEW ROUTE TO THE 12(S)CARBA-EUDISTOMIN SKELETON
• Anti Influenza Virus Activity of a Red-Fleshed Potato Anthocyanin
• A Novel Laccase Inhibitor, N-Hydroxyglycine, Produced by Penicillium citrinum YH-31
• Effects of Constituents from the Bark of Magnolia obovata on Nitric Oxide Production in Lipopolysaccharide-Activated Macrophages
• Intermolecular Association Model of Antifungal Polyene Macrolide via Concerted =C-H…O Interactions : X-ray Crystal Structure Analysis and Ab Initio Molecular-Orbital Calculations of Chainin
• Difference between Enzymatic and Chemical N-methylations of Protoberberine-Type Alkaloid, Dependent on the Stereoisomer of (-)-N-methyl-7, 8, 13, 13a-tetrahydroberberinium Salt
• New Farnesane-Type Sesquiterpenes, Hedychiols A and B 8,9-Diacetate, and Inhibitors of Degranulation in RBL-2H3 Cells from the Rhizome of Hedychium coronarium
• Insufficient Resistance of Trehalose-6, 6'-Dimycolate-Treated T-Cell Receptor δ Gene Mutant (TCR δ^) Mice against Influenza Virus Infection
• Synthesis of 1-Triazolyl-4-trimethylsilyl-2-butanol and 1-Triazolyl-5-trimethylsilyl-2-pentanol Derivatives and an Investigation of Their Fungicidal Activities
• Synthesis and Systemic Fungicidal Activity of Silicon-Containing Azole Derivatives
• Analysis of the Relationship between Cellular Thymidine Kinase Activity and Virulence of Thymidine Kinase-Negative Herpes Simplex Virus Types 1 and 2
• Protein-immobilized Electrode for Rapid and Convenient Sensing of Thyroid Hormone Receptor-ligand Interaction
• Piezo Electric Sensor for Endocrine-Disrupting Chemicals Using Receptor-co-factor Interaction
• Reinfection of cytomegalovirus in renal transplantation
• Inclusion Effect and Structural Basis of Cyclodextrins for Increased Extraction of Medicinal Alkaloids from Natural Medicines
• Herpesvirus Alkaline Deoxyribonuclease ; a Possible Candidate as a Novel Target for Anti-Herpesvirus Therapy
• Synthesis of (±)-trans- or cis-(5-Aminomethyltetrahydrofuranyl)imidazole by Mitsunobu Cyclization : Synthetic Studies toward Novel Histamine H_3 or H_4-Ligands
• Efficient and β-Stereoselective Synthesis of 4(5)-Methyl-5(4)-(5-amino-5-deoxy-β-D-ribofuranosyl)imidazole and Related Compounds Exhibiting Antiulcer Activity
• Meisenheimer Rearrangement of Azetopyridoindoles. VIII. Synthesis and Antiviral Activities of 12-Carbaeudistomin Analogs
• Meisenheimer Rearrangement of Azetopyridoindoles. V. Synthesis of 9-Methyl-12-carbaeudistomin and Related Compounds
• Association between antibody response against cytomegalovirus strain-specific glycoprotein H epitopes and HLA-DR
• Meisenheimer Rearrangement of Azetopyridoindoles. III. Synthesis of 3,6-Epoxyhexahydroazocino[5,4-b]indoles
• Efficient Synthesis of trans- or cis-4(5)-(5-Aminomethyltetrahydrofuran-2-yl)imidazoles via Diazafulvene Intermediates: Synthetic Approach toward Human Histamine H_4-Ligands
• Antiinflammatory Principles and Three New Labdane-Type Diterpenes, Hedychilactones A, B, and C, from the Rhizome of Hedychium coronarium Koeng
• Meisenheimer Rearrangement of Azetopyridoindoles. VI. Synthesis of 12-Carbaeudistomin and Related Compounds
• [3,3]Sigmatropic Ring Expansion of Cyclic Thionocarbonates. IV. Relatioship between Ring Size of Cyclic Thionocarbonates and Geometry of Created Double Bond in Medium- and Large-Membered Thiolcarbonates
• Reductive Deoxygenation of α, β-Unsaturated Ketones via Cyanophosphates by Lithium in Liquid Ammonia
• New Route to 1-(5-Imidazolyl)ribofuranoid Glycals from Ribofuranosyl Chloride and 5-Lithio-imidazole
• Studies on the [2,3]-Meisenheimer Rearrangement of 2-Vinylazetidine N-Oxides
• Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-α
• A New Synthesis of Allenic Nitriles from Ynones via Cyano Phosphates
• NEW ROUTE TO (Z)-ALLYLIC SULFIDES VIA A 10-MEMBERED THIOLCARBONATE
• Oral valganciclovir treatment for congenital cytomegalovirus infection
• A Simple One-Pot Synthesis of tert-Butyldimethylsilyl-Protected Cyanohydrins(Organic,Chemical)
• Reply from authors

もっと見る 閉じる

スポンサーリンク