A New Synthesis of Allenic Nitriles from Ynones via Cyano Phosphates

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概要

• 論文の詳細を見る

• Ynone cyanohydrin diethyl phosphates (cyano phosphates) 2 reacted regioselectively with higher-ordr cuprates 3,generated from 2-thienyl(cyano)copper lithium and n-butyl lithium, to give trisubstituted allenic nitriles 4 through an SN2' process in good yields. On the other hand, reaction of an excess of dialkyl copper lithium with ynone cyano phosphates 2 afforded allylic nitriles 5,via allenic nitriles 4.

• 公益社団法人日本薬学会の論文
• 1992-01-25

著者

• 春沢 信哉

  Osaka University of Pharmaceutical Sciences

• 米田 龍司

  Osaka University of Pharmaceutical Sciences

• 栗原 拓史

  大阪薬科大学

• 米田 龍司

  Agroscience Research Laboratories Sankyo Co. Ltd.

• 栗原 拓史

  Osaka College Of Pharmacy

• 稲垣 規子

  Osaka University of Pharmaceutical Sciences

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