Reaction of 3-[3-(2-Nitrophenyl)-2-propenylidene]-2,4-pentanedione with Hydroxylamine Hydrochloride. Formation of a 2-Chloromethyleneindolin-3-one
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概要
- 論文の詳細を見る
Reaction of 3-[3-(2-nitrophenyl)-2-propenylidene]-2,4-pentanedione (3) with hydroxylamine hydrochloride in methanol gave a 1 : 1 mixture of (E)-4-[3-methoxy-3-(2-nitrophenyl)-1-propenyl]-3,5-dimethylisoxazole (4) and (E)-4-[1-methoxy-3-(2-nitrophenyl)-2-propenyl]-3,5-dimethylisoxazole (5) in 49.3% yield. Similarly, when acetonitrile was used as the solvent in this reaction, 2-(3,5-dimethyl-4-isoxazolyl)-chloromethyleneindolin-3-one (6) (36.3%), (E)-4-acetyl-3-methyl-5-(2-nitrostyryl) isoxazole (7) (6.3%) and 4-[1-(hydroxyimino) ethyl]-3-methyl-7-(2-nitrophenyl)-1,2-oxazepine (8) (1.8%) were obtained.
- 公益社団法人日本薬学会の論文
- 1982-08-25
著者
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栗原 拓史
Osaka University of Pharmaceutical Sciences
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那須 啓子
Osaka College of Pharmacy
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水原 有美子
Osaka College of Pharmacy
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林 和江
Osaka College of Pharmacy
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栗原 拓史
Osaka College Of Pharmacy
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