Application of Cyanophosphates in Organic Synthesis. Reactivity of α-Cyano-α-diethylphosphonooxy Anions(Organic,Chemical)
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概要
- 論文の詳細を見る
The utility of the cyanohydrin diethylphosphates derived from aldehydes (arylaldehydes, crotonaldehyde, and cinnamaldehyde) as an acyl anion equivalent was examined. Deprotonation of cyanophosphates with n-butyllithium in the presence of tetramethylethylenediamine in tetrahydrofuran at -78℃ followed by reactions with alkyl(acyl) halides, carbonyl compounds, and α,β-nsaturated nitriles or esters, as well as cyanophosphates themselves, afforded alkylated (acylated) products, mixed benzoin and acyloin phosphates, polysubstituted cyclopropanes, and diarylfumaronitriles in moderate yields, respectively.
- 公益社団法人日本薬学会の論文
- 1987-12-25
著者
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春沢 信哉
Osaka University of Pharmaceutical Sciences
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米田 龍司
Osaka University of Pharmaceutical Sciences
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栗原 拓史
Osaka College Of Pharmacy
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山東 一孔
Osaka University Of Pharmaceutical Sciences
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