Allylic Rearrangement of Cyanophosphate. II. Synthesis of β-Cyano-α, β-unsaturated Ketones

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概要

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• Boron trifluoride-catalyzed allylic rearrangement of the cyanophosphates of α, β-unsaturated ketones (1a-d, 7 and 14) was found to give the allylic phosphates (3a-d, 9 and 16), which were successfully converted to β-cyano-α, β-unsaturated ketones (6a-d, 13 and 20) by acid hydrolysis (0.5 N HCl) followed by manganese dioxide oxidation of theresulting allylic alcohols (5a-d, 11,12 and 17). The stereochemical features of the allylic phosphates (9 and 6) are discussed.

• 公益社団法人日本薬学会の論文
• 1986-07-25

著者

• 春沢 信哉

  Osaka University of Pharmaceutical Sciences

• 米田 龍司

  Osaka University of Pharmaceutical Sciences

• 三木 益生

  Osaka College of Pharmacy

• 栗原 拓史

  Osaka College Of Pharmacy

• 三木 益生

  Osaka University Of Pharmaceutical Sciences

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