1,4-and 1,7-Addition Reactions of 4-(Substituted benzylidene)-3,5-dimethylisopyrazoles
スポンサーリンク
概要
- 論文の詳細を見る
Reactions of 4-(substituted benzylidene)-3,5-dimethylisopyrazoles (1a-1c) with acetic anhydride, hydrochloric acid in methanol, bromine in acetic acid, dimethyl sulfate, and acyl chlorides (acetyl chloride, benzoyl chloride, ethyl chloroformate, and p-toluenesulfonyl chloride) in pyridine gave 1,4-addition products (2-10) in fairly good yield. On the other hand, 4-(o-nitrobenzylidene) isopyrazole (1a) was converted to 5-chloro-3-(1-substituted 3,5-dimethylpyrazolyl) anthranils (13,14,and 15) by treatment with acetyl chloride, benzoyl chloride, or ethyl chloroformate without pyridine.
- 公益社団法人日本薬学会の論文
- 1978-04-25
著者
-
栗原 拓史
Osaka University of Pharmaceutical Sciences
-
平野 弘
Osaka College of Pharmacy
-
坂本 靖彦
(Present address)Research Laboratories, Nippon Shoji Kaisha, Ltd.,
-
坂本 靖彦
Osaka College of Pharmacy
-
坂本 靖彦
(present Address)research Laboratories Nippon Shoji Kaisha Ltd.
-
坂口 寿子
Osaka College of Pharmacy
-
栗原 拓史
Osaka College Of Pharmacy
関連論文
- Synthetic Studies of (±)-Lysergic Acid and Related Compounds(Organic,Chemical)
- Studies on Indenopyridine Derivatives and Related Compounds. VI. : Synthesis adn Stereochemistry of Ethyl 9.9-Dimethyl-1,2,3,9a-tetrahydro-9H-indeno[2,1-b]pyridine-3-carboxylate as a Possible Intermediate for the Total Synthesis of Lysergic Acid
- A NEW SYNTHESIS OF (±)-LYSERGIC ACID
- Improved Synthesis of 5'-Deoxy-5'-adenosineacetic Acid
- Thermal Elimination of Carbonyl Sulfide from O-Aryl Thionocarbonates of Pyrrolidine-, Piperidine-, and Tetrahydrothiophene-2-ethanol
- Novel Transformation of Azabicyclothionocarbonate to Azaspirolactone
- Molecular Conformations of Aminophenylimidazoles Exhibiting Antiulcer Activities
- NEW ASPECTS OF THE 1,3-DIPOLAR CYCLOADDITION OF THIAZOLIUM N-IMINES WITH DIMETHYL ACETYLENEDICARBOXYLATE (DMAD)
- Studies on Ergot Alkaloids and Related Compounds. XIV. Syntheses of N-Alkyl-4-methyl-2,3,4,4a, 5,6-hexahydrobenzo [f] quinoline-2-carboxamides and Stereochemistry of Diethyl 4-Methyl-1-oxo-1,2,3,4,4a, 5,6,10b-octahydrobenzo [f] quinoline-2,2-dicarboxylate
- Studies on Ergot Alkaloids and Related Compounds. XIII. syntheses and Stereochemistries of 4-Methyl-1,2,3,-4,4a, 5,6,10b-octahydrobenzo[f]quinoline-2-carboxylic Acids
- Studies on 1,4-Benzothiazines. IV. Reactions of 2-Acyl-4H-1,4-benzothiazines with Hydroxylamine, Hydrazine, Guanidine and Acetamidine
- 1,3-DIPOLAR CYCLOADDITION OF THIAZOLIUM N-PHENYLIMIDES WITH ACRYLONITRILE
- 2. チアミン-O-インドール-3-ブロピオネートにおけるピリミジン核とインドール核のスタッキング : 第268回会議研究発表要旨 : ビタミンB研究委員会
- 1,4-Benzothiazineに関する研究(第3報)2-Acyl-4-methylbenzothiazine類およびその関連化合物の反応性
- ビタミンB_1とブロムシアンの反応におけるO-カルバモイルチオクロームの生成について
- 2.チアミンとブロムシアンとの反応生成物(ビタミンB研究委員会 : 第260回会議研究発表要旨)
- Studies on 1,4-Benzothiazines. II. Acetylation of 2,3-Dihydro-3-imino-4H-1,4-benzothiazine
- リポ酸の生合成におけるn-オクタン酸への硫黄の導入
- Studies on 1,4-Benzothiazines. I. Synthesis of 2,3-Dihydro-3-imino-4H-1,4-benzothiazines and Acetylation of the N-Methyl Derivative
- Isoalloxazine関連化合物の新しい合成法
- d-ビオチンの立体特異的全合成
- イソビオプテリンの副生を伴わぬビオプテリンの合成
- チアミンとその関連化合物の新しい分解と合成反応に関する研究
- キノリン-3-酢酸誘導体の合成とその生理活性
- Meisenheimer Rearrangement of Azetopyridoindoles. VII. Ring Expansion of 2-Phenylhexahydroazeto[1', 2' : 1,2]pyrido[3,4-b]indoles by Oxidation with m-Chloroperbenzoic Acid
- [3,3]Sigmatropic Ring Expansion of Cyclic Thionocarbonates. VII. On the Formation of 8-Membered Thionocarbonates as the Intermediates
- [3,3]Sigmatropic Ring Expansion of Cyclic Thionocarbonates. VI. Regioselective Wohl-Ziegler Bromination of 10-Membered Thiolcarbonates
- Chemistry of Tetrahydro-1,3-oxazin-2-one : New Method for the Synthesis of Indoloquinolizidine Derivatives
- MEISENHEIMER REARRANGEMENT OF 2-ETHENYL-1,4,5,10b-TETRAHYDRO-2H-AZETOPYRIDO[3,4-b__-]INDOLE N-OXIDES : NEW ROUTE TO THE 12(S)CARBA-EUDISTOMIN SKELETON
- Reductive Cyclization of o-Nitrobenzylideneacetylacetone Analogues
- Studies on Indenopyridine Derivatives and Related Compounds. III. Stereochemistry of 1-Substituted 4,9-Dihydroxy-9-phenyl-1,2,3,4,4a, 9a-hexahydro-9H-indeno [2,1-b] pyridines
- Reaction of Pyrazolo [1,5-α] pyrimidine Derivatives with Nucleophiles. V. X-Ray Determination of the Molecular Structure of a Reaction Product of 6,7-Diethoxycarbonylpyrazolo [1,5-α] pyrimidine-3-carbonitrile with N-Methylindole
- Reactions of Cyclic-enaminoketones with Diacylethylenes. Regioselective Synthesis of 4-Oxotetrahydroindole, 5-Oxotetrahydroquinoline, Pyrrolo- and Pyrido [2,3-d] pyrimidines
- A New Method for the Preparation of 2-Hydroxymethyl-3-quinolinecarboxylic Acid Lactone Derivatives
- Reactions of Pyrazolo [1,5-α] pyrimidine Derivatives with Nucleophiles. IV. Some Reactions of 1,4-Dihydrocyclopent [b] indoles
- THE REACTION OF 1,4-DIHYDROCYCLOPENT [b] INDOLES WITH DIMETHYL ACETYLENEDICARBOXYLATE
- Reaction of 3-[3-(2-Nitrophenyl)-2-propenylidene]-2,4-pentanedione with Hydroxylamine Hydrochloride. Formation of a 2-Chloromethyleneindolin-3-one
- Reactions of Pyrazolo [1,5-a] pyrimidine Derivatives with Nucleophiles. III. Nucleophilic Addition to 6,7-Bis (ethoxycarbonyl) pyrazolo [1,5-a] pyrimidine-3-carbonitrile in the Presence of Triethyloxonium Fluoroborate
- Synthesis and Reactions of Ethyl 6-Acetyl-2,3-diphenylimidazo [1,2-a] pyrimidine-5-carboxylate and Related Compounds
- SYNTHESIS AND X-RAY CRYSTAL STRUCTURE DETERMINATION OF 1,4-DIHYDROCYCLOPENT [b] INDOLES
- Ring Transformations of 6H-Cyclopropa [e] pyrazolo [1,5-a] pyrimidine. III. Synthesis and X-Ray Crystal Structure Determination of a 1-Pyrazol-3-ylpyrrole-2-carboxylic Acid
- Reactions of Pyrazolo [1,5-α] pyrimidine Derivatives with Nucleophiles. I. Nucleophilic Addition to 6,7-Dicarbethoxypyrazolo [1,5-α]-pyrimidine-3-carbonitrile in the Presence of Boron Trifluoride Etherate
- Ring Transformations of 6H-Cyclopropa[5a, 6a]pyrazolo[1,5-a]pyrimidine. II. Reaction of 5a-Acetyl-6a-carbethoxy-5a, 6a-dihydro-6H-cyclopropa[5a, 6a]pyrazolo[1,5-a]pyrimidine-3-carbonitriles with N-Methylaniline
- Reactions of Ethyl 3-Ethoxymethylene-2,4-dioxovalerate and Ethyl Ethoxymethyleneoxaloacetate with Indole Analogs
- Studies on Ergot Alkaloids and Related Compounds. XII. Syntheses of Ethyl 4-Methyl-2,3,4,4α, 5,6-hexahydrobenzo[f]quinoline-2-carboxylate and its Dihydro Derivative
- Formation of 2-Acetyl-3-hydroxy-5-phenylmaleimide from Ethyl 3-Ethoxy-methylene-2,4-dioxovalerate and Phenylhydroxylamine
- Studies on Ergot Alkaloids and Related Compounds. XVI. On the So-called Bohlmann Absorption of 2,4-Disubstituted Octahydrobenzo [f] quinoline Derivatives
- Studies on Ergot Alkaloids and Related Compounds. XV. Reductions of cis- and trans-4-Methyl-2-methylen-3-oxo-1,2,3,4,4a, 5,6,10b-octahydrobenzo [f] quinolines and Preparation of trans-syn-2,4-Dimethyl-1,2,3,4,4a, 5,6,10b-octahydrobenzo-[f] quinoline
- REACTION OF METHYL VINYL KETONE CYANOHYDRIN PHOSPHATE WITH AROMATIC COMPOUNDS
- Meisenheimer Rearrangement of Azetopyridoindoles. V. Synthesis of 9-Methyl-12-carbaeudistomin and Related Compounds
- 2-Acetyl-3-hydroxymaleimide誘導体の反応性(第1報)アミン類との反応について
- 1,4-and 1,7-Addition Reactions of 4-(Substituted benzylidene)-3,5-dimethylisopyrazoles
- Reaction of 4-(o-Nitrobenzylidene)-3,5-dimethylisopyrazole with Acyl Chlorides
- Studies on Indenopyridine Derivatives and Related Compounds. I. Syntheses and Stereochemistries of 1-Substituted 1,2,3,4,4a, 9a-Hexahydro-4-hydroxy-9H-indeno [2,1-b] pyridines and Related Compounds
- Preparation of Thiamine from Dihydrothiamine
- A NEW SYNTHESIS OF BIARYLS
- Meisenheimer Rearrangement of Azetopyridoindoles. III. Synthesis of 3,6-Epoxyhexahydroazocino[5,4-b]indoles
- Meisenheimer Rearrangement of Azetopyridoindoles. VI. Synthesis of 12-Carbaeudistomin and Related Compounds
- Application of Cyanophosphates in Organic Synthesis. Reactivity of α-Cyano-α-diethylphosphonooxy Anions(Organic,Chemical)
- Allylic Rearrangement of Cyanophosphates. III. : Reaction of Acyclic Enone Cyanophosphates
- Studies on Isopyrazole Derivatives and Related Compounds. I. Structure of Condensation Product of Nitrobenzylideneacetylacetone with Hydrazine Dihydrochloride
- [3,3]Sigmatropic Ring Expansion of Cyclic Thionocarbonates. IV. Relatioship between Ring Size of Cyclic Thionocarbonates and Geometry of Created Double Bond in Medium- and Large-Membered Thiolcarbonates
- Reductive Deoxygenation of α, β-Unsaturated Ketones via Cyanophosphates by Lithium in Liquid Ammonia
- Synthesis and Cycloaddition Reaction of 2-Cyano-3-indoleacetonitriles
- CYANOPHOSPHORYLATION OF KETONES AND ALDEHYDES USING DIETHYL PHOSPHOROCYANIDATE (DEPC)
- New Route to 1-(5-Imidazolyl)ribofuranoid Glycals from Ribofuranosyl Chloride and 5-Lithio-imidazole
- RECYCLISATION OF 2-OXOTETRAHYDRO-1,3-OXAZINES ACCOMPANIED BY DECARBOXYLATION : A CONVENIENT SYNTHESIS OF TETRAHYDROPYRIDINE, QUINOLIZIDINE, AND INDOLIZIDINE SKELETONS
- A New Synthesis of Allenic Nitriles from Ynones via Cyano Phosphates
- NEW ROUTE TO (Z)-ALLYLIC SULFIDES VIA A 10-MEMBERED THIOLCARBONATE
- Allylic Rearrangement of Cyanophosphate. II. Synthesis of β-Cyano-α, β-unsaturated Ketones
- ALLYLIC REARRANGEMENT OF α, β-UNSATURATED KETONE-DIETHYL PHOSPHOROCYANIDATE ADDUCTS