Ring Transformations of 6H-Cyclopropa[5a, 6a]pyrazolo[1,5-a]pyrimidine. II. Reaction of 5a-Acetyl-6a-carbethoxy-5a, 6a-dihydro-6H-cyclopropa[5a, 6a]pyrazolo[1,5-a]pyrimidine-3-carbonitriles with N-Methylaniline

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概要

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• The reaction of 5a-acetyl-6a-carbethoxy-5a, 6a-dihydro-6H-cyclopropa [5a, 6a] pyrazolo [1,5-a] pyrimidine-3-carbonitrile (1) with N-methylaniline in refluxing benzene for 20 min afforded four ring-transformed products, namely ethyl E- and Z-β-N-methylanilino-6-pyrazolo [1,5-a] pyrimidineacrylates (8 and 9), N-pyrazolylpyrrole (10) and N-pyrazolylpyridone (11), together with 4,7-dihydro-7-(N-methylanilino) methylpyrazolo [1,5-a] pyrimidine (7). However, the reaction of 2 possessing a methyl group at the 5-position of 1 with N-methylaniline in refluxing xylene gave the 5-methyl derivative of 7 (13) and 5-methylpyrazolo [1,5-a] pyrimidine (14), together with N, N-dimethylaniline. The mechanism of formation of compounds 8,9,10,and 11 is discussed.

• 公益社団法人日本薬学会の論文
• 1981-06-25

著者

• 栗原 拓史

  Osaka University of Pharmaceutical Sciences

• 那須 啓子

  Osaka College of Pharmacy

• 谷 力

  Osaka College of Pharmacy

• 栗原 拓史

  Osaka College Of Pharmacy

関連論文

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