Meisenheimer Rearrangement of Azetopyridoindoles. V. Synthesis of 9-Methyl-12-carbaeudistomin and Related Compounds

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概要

• 論文の詳細を見る

• 9-Methyl-12-carbaeudistomin (1,13b-cis-1-amino-13-methyl-1,2,3,4,7,8,13,13b-octahydro[1', 2']oxazepino-[2', 3', : 1,2]pyrido[3,4-b]indole) (2), which has a carbon atom instead of the sulfur atom in the D-ring of tetracyclic eudistomins (1), its 1,10-trans isomer (3), and their 11,12-didehydro derivatives (4 and 5) were synthesized from 2-vinylazetopyridoindoles (8 and 17) via the [2,3]-Meisenheimer rearrangement of the corresponding N-oxides, for structure-activity relationship study of edistomins (1). Similarly, 5-amino-3,6-epoxyhexahydroazocino[5,4-b]-indoles (6 and 7) were synthesized from 2-ethylazetopyridoindole (33) via the [1,2]-Meisenheimer rearrangement of the corresponding N-oxide.

• 公益社団法人日本薬学会の論文
• 1994-01-15

著者

• 春沢 信哉

  Osaka University of Pharmaceutical Sciences

• 栗原 拓史

  Osaka University of Pharmaceutical Sciences

• 米田 龍司

  Osaka University of Pharmaceutical Sciences

• 酒井 朋子

  Osaka University Of Pharmaceutical Sciences

• 栗原 拓史

  大阪薬科大学

• 高井 雅人

  Osaka University of Pharmaceutical Sciences

• 塚本 貴庸子

  Osaka University Of Pharmaceutical Sciences

• 米田 龍司

  Agroscience Research Laboratories Sankyo Co. Ltd.

• 坂本 靖彦

  Osaka College of Pharmacy

• Sakamoto Y

  Alfresa Pharma Co.

• 栗原 拓史

  Osaka College Of Pharmacy

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