Studies on 1,4-Benzothiazines. IV. Reactions of 2-Acyl-4H-1,4-benzothiazines with Hydroxylamine, Hydrazine, Guanidine and Acetamidine
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概要
- 論文の詳細を見る
2-Acyl-4-methyl-4H-1,4-benzothiazines (1a, b) reacted with hydroxylamine to give dihydroisoxazolo [4,5-b] [1,4] benzothiazines (3a, b). However, the reaction of 1a with hydrazine did not give the dihydropyrazolo [4,5-b] [1,4] benzothiazine derivative corresponding to 3a, but gave its dehydro compound (6). On the other hand, in the reaction of 1b with hydrazine, formation of a pyrazole ring and opening of the thiazine ring occurred to afford a 4-(2-aminophenylthio) pyrazole derivative (7). Guanidine and acetamidine also reacted with 1a, b to give 5-[2-(N-methylamino) phenylthio] pyrimidines (10a-d).
- 社団法人日本薬学会の論文
- 1984-04-25
著者
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平野 弘
Osaka College of Pharmacy
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杉山 和明
Osaka College of Pharmacy
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山下 まゆみ
Osaka College of Pharmacy
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高松 正典
Osaka College of Pharmacy
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飛岡 孝子
Osaka College of Pharmacy
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高松 正典
Osaka College Of Pharmacy:(present Address)pharmaceuticals Research Center Kanebo Ltd.
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