Inclusion Effect and Structural Basis of Cyclodextrins for Increased Extraction of Medicinal Alkaloids from Natural Medicines

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概要

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• The enhancing effects of α-, β-, and γ-cyclodextrins (CyDs) on the aqueous extraction of ephedrine and berberine from the natural medicines were investigated in HPLC analysis, and the greatest effect was observed for β- and γ-CyDs. To clarify the structural basis of such an increased extraction effect with β-CyD, possible interaction modes of (1R,2S)-ephedrine with α-, β-, and γ-CyDs were investigated using molecular dynamic simulations in an aqueous solution system. It was shown that the wrapping model of ephedrine by β-CyD is the most compact and thus increases the solubility most effectively, compared with those by other CyDs. The same mode could be possible for the greatest effect of γ-CyD on the extraction of berberine from natural medicines. This clearly shows that CyDs are useful additives for the effective extraction of bioactive alkaloids from natural medicines.

• 公益社団法人日本薬学会の論文
• 2007-05-01

著者

• 石田 尚行

  電気通信大量子物質工

• 石田 尚之

  電通大電気通信学部

• ISHIDA Toshimasa

  Osaka University of Pharmaceutical Sciences

• KAMIGAUCHI Miyoko

  Kobe Pharmaceutical University

• OHISHI Hirofumi

  Osaka University of Pharmaceutical Sciences

• KAWANISHI Kazuko

  Kobe Pharmaceutical University

• Iwashita T

  Suntory Institute For Bioorganic Research

• Ishida T

  Departments Of Biochemistry Shiga University Of Medical Science

• Ishida Toshimasa

  Osaka Univ. Of Pharmaceutical Sciences

• Ishida Toshimasa

  Dep. Of Physical Chemistry Osaka Univ. Of Pharmaceutical Sciences

• Ishida Toshimasa

  Osaka College of Pharmacy

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