Effect of DNA on Filament Formation of Tau Microtubule-Binding Domain : Structural Dependence of DNA

スポンサーリンク

概要

• 論文の詳細を見る

• To examine whether or not DNA accelerates the paired helical filament (PHF) formation of tau, the effect of various types of DNAs on filament formations of three-repeated and four-repeated microtubule-binding domains (3RMBD and 4RMBD, respectively) of tau protein was investigated by monitoring the change of thioflavin S fluorescence intensity, that is parallel to the filament formation. Consequently, the followings were clarified: 1) the structurally rigid double-stranded DNA such as poly(dG-dC) or calf thymus DNA has the high potency of promoting the filament formations of 3RMBD and 4RMBD, 2) the filament formation of 3RMBD was more promoted than that of 4RMBD, due to the intermolecular dimer formation of 3RMBD, 3) the DNA-promoted filament formations of these MBDs were temperature-dependent, and the single-stranded DNA such as poly(dA) or poly(dT) reversely protected 4RMBD from the molecular assembly at 20℃. These are the first report on the function of DNA for the PHF formation of tau protein.

• 2007-07-01

著者

• 石田 尚行

  電気通信大量子物質工

• 石田 尚之

  電通大電気通信学部

• ISHIDA Toshimasa

  Osaka University of Pharmaceutical Sciences

• TOMOO Koji

  Department of Pyysical Chemistry, Osaka University of Pharmaceutical Sciences

• ISHIDA Toshimasa

  Department of Pyysical Chemistry, Osaka University of Pharmaceutical Sciences

• MINOURA Katsuhiko

  Osaka University of Pharmaceutical Sciences

• MINOURA Katsuhiko

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• Ishida Toshimasa

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• TOMOO Koji

  Osaka University of Pharmaceutical Sciences

• Koji Tomoo

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Tomoo Koji

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Iwashita T

  Suntory Institute For Bioorganic Research

• Doumoto Michiko

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• MIZUSHIMA Fumie

  Osaka University of Pharmaceutical Sciences

• HIKOSOU Rie

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• KURABAYASHI Yasuko

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• HOSHITOKU Kaoru

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• MIZUSHIMA Fumie

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• Hikosou Rie

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Minoura K

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Hoshitoku Kaoru

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Kurabayashi Yasuko

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Ishida Toshimasa

  Dep. Of Physical Chemistry Osaka Univ. Of Pharmaceutical Sciences

関連論文

• 27aQJ-11 RE-3dヘテロ金属分子磁性体の交換相互作用と磁性(量子スピン系(二次元系及びその他),領域3,磁性,磁気共鳴)
• 20aQH-7 RE-3dヘテロ金属分子磁性体の交換相互作用と磁性(20aQH 量子スピン系(クラスター系及び一般),領域3(磁性,磁気共鳴))
• Studies on the Constituents of Cimicifuga Species. XX. Absolute Stereostructures of Cimicifugoside and Actein from Cimicifu simplex WORMSK.
• Illumination-induced Magnetization Enhancement of the Weak Ferromagnet [Fe(N_3)_2(pm)] (pm = Pyrimidine)
• 24pPSB-2 S=1/2反強磁性鎖の磁化過程における交替磁場の影響(量子スピン系,化合物磁性,スピングラス・ランダム系,アモルファス系,フラストレーション系,磁気共鳴一般,磁性一般,領域3(磁性,磁気共鳴))
• 27aPS-106 S=1/2一次元反強磁性鎖Cu-pyrimidineの強磁場磁化過程(領域3ポスターセッション : 希土類合金,化合物磁性,薄膜・人工格子,スピングラス,フラストレーション,量子スピン系,実験技術開発等)(領域3)
• 21aTC-8 交替磁場が存在する 1 次元反強磁性鎖 Cu-pyrimidine の強磁場磁化
• 超分子的に制御できる分子磁性
• Low - Temperature Magnets M[N(CN)_2]_2(pyrimidine)(M=Fe and Co) with a 3 - D Network
• One-Dimensional S=1 Ferromagnetic Chain Formed by a Square Ni_2S_2Motif in Ni(qt)_2(qt=Quinoline-8-thiolate)
• The Experimental Deformation Electron-Density Distributions of 4-Arylmethyleneamino-2,2,6,6-tetramethyl-1-piperidyloxyl (TEMPO) Radicals: Relations between Electron Densities and Intermolecular Interactions
• 27aYQ-12 有機磁性体4-Py-CH=N-TEMPOのμSR研究
• 30p-J-6 μSR実験法を用いた有機ラジカル強磁性体Ar-CH=N-TEMPOの磁性研究II
• 30p-J-4 有機強磁性体p-Cl-C_6H_4CH=N-TEMPOにおける圧力誘起強磁性-反強磁性転移
• Ferromagnetic and Antiferromagnetic Phases of 4-(4-Iodobenzylideneamino)-2,2,6,6-tetramethylpiperidin-1-yloxyl
• 28a-YH-5 μSR実験法を用いた有機ラジカル強磁性体Ar-CH=N-TEMPOの磁性研究
• Pyrimidine-Bridged Cobalt(II) Complexes with a Chiral 3-D Network Showing Weak Ferromagnetism
• 1p-Y-13 μSR実験法を用いた有機ラジカル強磁性体Ph-CH=N-TEMPOの磁性研究
• 1p-Y-12 有機強磁性体TEMPOの加圧効果
• 6a-YH-2 μSR実験法を用いた有機ラジカル強磁性体Ar-CH=N-TEMPOの磁性研究
• Ferromagnetic Dimer of π-Conjugated Organic Free Radicals 9, 9-Bis(p-tolyl)-9, 10-dihydroacridin-10-yloxyl
• Comparison of Conformations of Tetrapeptide Diastereomers Containing α-Phenyl-α-(2-pyridyl)glycine
• 超分子的に制御できる分子磁性
• Crystallization and Preliminary X-Ray Diffraction Study of Recombinant Human Eukaryotic Initiation Factor-4E
• Structual Analyses for Asymmetric Derivatives of Ascidiacyclamide by X-ray Diffraction and NMR Spectroscopy
• X-Ray Molecular and Crystal Structure of Imidazolopyrroloquinoline, a Main Reaction Product of Pyrroloquinolinequinone (PQQ) and L-Tryptophan in Vitro
• Unusual Intermolecular Short Contacts of C…C = 2.3Å in Crystal Structure of Copper Complex of Schiff Base of Vitamin B_6 Phosphate Ester; Does It Reveal an Intermediate Structure to σ-Covalent Bond Formation ?
• Crystal Structure of Hybrid Dipeptide, (2-Carboxyethyl)-cytosine-1-yl-L-threonine Monohydrate
• Crystal Structure of Hybrid Dipeptide, Cytosinyl-L-tyrosine
• Conformation and Sodium Coordinate Forms of an Endothelin Inhibitor BQ123・Na, Cyclo(-D-Trp-D-Asp^~-Pro-D-Val-Leu-)・Na^+, in the Crystal
• Polymorphism and C-H…O Interaction of Wortmannin, a Phosphatidylinositol 3-Kinase Inhibitor
• Crystal Structure of 3, 4-Dihydroxy-6-fluoro-DL-phenylalanine Monohydrate Used as a Positron Emission Tomography Imaging Ligand
• Interaction Modes between N7-Quarternized Guanine and Cytosine-Containing Dipeptides
• Crystal Structure of Hybrid Dipeptide, Uracil-1-yl-(2-carboxyethyl)-glycine
• Crystal Structure of Cytosine and Alanine Hybrid Dipeptide, Cytosine-1-yl-(2-carboxyethyl)-L-alanine
• Metal-Azide-Pyrimidine Complexes M(N_3)_2(pm) with a Three-Dimensional Network Showing Weak Ferromagnetism for M = Mn and Fe and Antiferromagnetism for M = Co and Ni
• Low-Temperature Heat Capacities and Ferromagnetic Phase Transition of the Organic Free Radical Ferromagnet, 4-(4-Chlorobenzylideneamino)-2,2,6,6-tetramethylpiperidin-1-oxyl (CATMP)
• Aggregation Feature of Fluorine-Substituted Benzene Rings and Intermodular C-H…F Interaction: Crystal Structure Analyses of Mono- and Trifluoro-L-phenylalanines
• Turnip Mosaic Virus Genome-Linked Protein VPg Binds C-Terminal Region of Cap-Bound Initiation Factor 4E Orthologue Without Exhibiting Host Cellular Specificity
• Opioid Peptide-Like Activities of Fulicin, Fulicin Gene-Related Peptides, and Their Synthetic Analogs
• μSR of the Organic Radical Ferromagnet, 4-(p-Chlorobenzylideneamino)-2, 2, 6, 6-tetramethylpiperidin-1-yloxyl
• Organic Radicals Exhibiting Intermolecular Ferromagnetic Interactions with High Probability: 4-Arylmethyleneamino-2,2,6,6-tetramethylpiperidin-1-yloxyls and Related Compounds
• Study on the Structure Activity Relationship of a Phytosiderophore, Mugineic Acid
• Study on the Relationship between Structure and Metal Complexation Ability of Mugineic Acid
• Domain-dependent Interaction of Eukaryotic Initiation Factor eIF4A for Binding to Middle and C-terminal Domains of eIF4G
• Role of Each Repeat Peptide in Aggregation of Tau Microtubule-binding Domain
• Effect of DNA on Filament Formation of Tau Microtubule-Binding Domain : Structural Dependence of DNA
• Marked Difference Between Self-aggregations of First and Fourth Repeat Peptides on Tau Microtubule-binding Domain in Acidic Solution
• Crystal Structure of Ubiquitin-Like Domain of Murine Parkin
• Study of Self-Aggregation Mechanism of Microtubule-Binding Domain of Tau Protein
• Effect of N-Terminal Region of eIF4E and Ser65-Phosphorylation of 4E-BP1 on Interaction between eIF4E and 4E-BP1 Fragment Peptide
• N-terminal Secondary Structures of Second and Third Repeat Fragments Responsible for Self-assembly of Tau Microtubule-binding Domain
• PH-Dependent Filament Formation of Repeat Peptide of Microtubule-binding Domain of Tau Protein
• Possible Role of Each Repeat Structure of the Microtubule-Binding Domain of the Tau Protein in In Vitro Aggregation
• Solvent-dependent Conformational Change of Third Repeat Fragment of Microtubule-binding Domain Responsible for Filament Formation of Tau Protein
• Crystal and Molecular Structure of an (S)-(+)-Enantiomer of Modafinil, a Novel Wake-Promoting Agent
• Conformational Analysis of Four Repeat Fragments in Tau Microtuble Binding Domain
• Analysis of aggregation mechanism of microtuble binding domain in tau protein
• Proposed Mechanism of Ferromagnetic Interaction of Organic Ferromagnets : 4-(Arylmethyleneamino)-2,2,6,6-tetramethylpiperidin-1-oxyls and Related Compounds
• Ferromagnetism in Organic Radical Crystal of 4-(p-Chlorobenzylideneamino)-2,2,6,6-tetramethylpiperidin-1-oxyl
• Syntheses and Structures of Novel Fused-Ring Systems Containing Six or Seven Sulfur Atoms : 2,3:5,6-Bis(ethylenedithio)thieno[3,2-b]thiophene and 3,4:6,7-Bis(ethylenedithio)thieno[3,2-c][1,2]dithiin
• An Organic Ferromagnet with a Tc of 0.4 K. 4-(p-Phenylbenzylideneamino)-2,2,6,6-tetramethylpiperidin-1-oxyl
• A New Organic Ferromagnet: 4-Benzylideneamino-2,2,6,6-tetramethylpiperidin-1-oxyl
• Enantioselective Synthesis of a Phenylalanine Library Containing Alkyl Groups on the Aromatic Moiety : Confirmation of Stereostructure by X-Ray Analysis
• Binding Diversity of a Noncovalent-Type Low-Molecular-Weight Serine Protease Inhibitor and Function of a Catalytic Water Molecule : X-Ray Crystal Structure of PKSI-527-Inhibited Trypsin
• Intermolecular Association Model of Antifungal Polyene Macrolide via Concerted =C-H…O Interactions : X-ray Crystal Structure Analysis and Ab Initio Molecular-Orbital Calculations of Chainin
• Difference between Enzymatic and Chemical N-methylations of Protoberberine-Type Alkaloid, Dependent on the Stereoisomer of (-)-N-methyl-7, 8, 13, 13a-tetrahydroberberinium Salt
• Functional Analysis of C-Terminal Amide in Bioactivity of Endomorphin-2 : Conformational Comparison with Its Unamidated Peptide in DMSO Solution
• Structural/Physicochemical Properties of Corycavidine, a Key Intermetabolite in the Biosynthesis of Isoquinoline Alkaloids, Elucidated by X-Ray Crystallography, Solution Conformation and Thermal Behavior Analyses, and Energy Calculations
• Copper(II) Ion-Catalyzed and Molecular Packing-Dependent Dimerization of Pyridoxal 5-Phosphate-Pyridoxamine 5-Phosphate Schiff Base as a Structural Model for in Vitro Transformation of Amino Acid by Pyridoxal 5-Phosphate : X-Ray Crystal Structural investi
• Molecular Ferromagnet, PM[VO(hfac)_2]_2 (PM=pyrimidine, hfac = 1,1,1,5,5,5-hexafluoropenta-2,4-dionate). Ferromagnetic Assembly of Ground High-Spin Molecules
• Structural Requirement for Chiral Recognition of Amino Acid by (18-Crown-6)-tetracarboxylic Acid : Binding Analysis in Solution and Solid States
• Conformational Comparison of μ-Selective Endomorphin-2 with its C-Terminal Free Acid, Studied by ^1H-NMR Spectroscopy and X-Ray Structure Analysis
• Molecular Cynamics Simulations of Bovine Cathepsin B and Its Complex with CA074
• Substrate Specificity of Bovine Cathepsin B and Its Inhibition by CA047, Based on Crystal Structure Refinement of the Complex
• Comparison of Efficiencies of the Fused Heterocyclic Compounds, 9H-Xanthene-2, 7-diols, and Related Chain-Breaking Phenolic Antioxidants
• Characterization of an End Product in a Copper(II)-Mediated Nonenzymatic Reaction of Vitamin B_6 with Amino Acid: X-Ray Crystal Structure of a Dimer of Cu(II). [Pyridoxal 5-Phosphate-Pyridoxamine 5-Phosphate Schiff Base]. 7H_2O
• Binding Mode of CA074, a Specific Irreversible Inhibitor, to Bovine Cathepsin B as Determined by X-Ray Crystal Analysis of the Complex
• The Curie Temperature of Anisotropic Heisenberg Ferromagnet with Mixed Spins of S=1/2 and S=1
• Structural Studies of C-Amidated Amino Acids and Peptides : Crystal Structures of Z-Gly-Phe-NH_2,Tyr-Lys-NH_2,and Asp-Phe-NH_2
• Solvent-Dependent Conformation of the Third Repeats Fragment in the Microtubule-Binding Domain of Tau Protein, Analyzed by ^1H-NMR Spectroscopy and Molecular Modeling Calculation
• Aggregation Analysis of the Microtubule Binding Domain in Tau Protein by Spectroscopic Methods
• Inhibitory Behavior of Cyanidine and Methylene Blue for Filament Formation of Tau Microtubule-binding Domain
• Structural Studies of [2',6'-Dimethyl-L-tyrosine^1]Endomorphin-2 Analogues Containing Proline Mimics
• Importance of Tyrosine Residue for Filament Formation of Tau Microtubule-binding Domain
• Structural Scaffold of 18-Crown-6 Tetracarboxylic Acid for Optical Resolution of Chiral Amino Acid : X-Ray Crystal Analyses of Complexes of D- and L-Isomers of Serine and Glutamic Acid
• Conformational Study of Repeat Fragments in Microtuble Binding Domain of Tau Protein
• Aggregation Analysis of Microtubule Binding Domain in Tau Protein by Spectroscopic Method
• Total Synthesis of cis,cis-Ceratospongamide and It's Thermal Isomerization : What is the Real Structure of the Isomerization Product?
• Inclusion Effect and Structural Basis of Cyclodextrins for Increased Extraction of Medicinal Alkaloids from Natural Medicines
• Molecular Conformation of Aureobasidin A, a Potent Antifungal Cyclic Depsipeptide : X-Ray Structure Analysis
• Intermolecular Ferromagnetic Interaction of 4-Benzylideneamino-2,2,6,6-tetramethylpiperidin-1-oxy1
• Intermolecular Ferromagnetic Interaction of 4-(2-Naphthylmethyleneamino)-2,2,6,6-tetramethylpiperidin-1-oxyl
• Importance of Tyr310 residue in the third repeat of microtubule binding domain for filament formation of tau protein
• 希釈冷凍機を用いた極低温のミューエスアール
• Pyrimidines as Ferromagnetic Exchange Couplers in Dinuclear Oxovanadium(IV) Coplexes
• Importance of CH-π Interaction Between I308 and Y310 Residues in the Third Repeat of Microtubule Binding Domain for Tau Filament Formation
• Comparison of the Efficiencies of the Fused Heterocyclic Compounds, 9H-Xanthene-2,7-diols, and Related Chain-Breaking Phenolic Antioxidants
• Synthesis and Conformational Analysis of Dcp-Containing Homo-Oligopeptides
• CH-π Interaction between I308 and Y310 Residues is Required for Self Assembly of Full Length Tau

もっと見る 閉じる

スポンサーリンク