Aggregation Feature of Fluorine-Substituted Benzene Rings and Intermodular C-H…F Interaction: Crystal Structure Analyses of Mono- and Trifluoro-L-phenylalanines

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概要

• 論文の詳細を見る

• X-Ray crystal structures of four different fluorine-substituted phenylalanines (two mono- and two tri-substitutions) were analyzed to investigate the effect of fluorine atom on the association pattern of benzene rings. Although respective structures showed similar molecular packing in such a way that the layers of hydrophobic benzene rings and hydrophilic amino/carboxyl groups were alternately running along a crystallographic axis, the association patterns of benzene rings were different depending on the substitution position and number of fluorine atoms. The general features could be that the partially displaced face-to-face interactions are increased with increase in the number of fluorine atoms, whereas the edge-to-face interactions are decreased. The C-H bond next to a fluorine-substituted carbon atom could serve as a donor of an intermolecular C-H…F hydrogen bond.

• 社団法人日本薬学会の論文
• 2003-11-01

著者

• 石田 尚行

  電気通信大量子物質工

• SHIMOHIGASHI Yasuyuki

  Laboratory of Structure-Function Biochemistry, Department of Chemistry, Kyushu University

• 石田 尚之

  電通大電気通信学部

• 石田 尚之

  電通大量子物質工

• IN Yasuko

  Osaka University of Pharmaceutical Sciences

• Shimohigashi Yasuyuki

  Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University

• NOSE Takeru

  Laboratory of Biochemistry, Department of Chemistry, Faculty of Science, Kyushu University

• In Y

  Osaka Univ. Pharmaceutical Sci. Osaka Jpn

• In Yasuko

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Nose Takeru

  Laboratory Of Structure-function Biochemistry Department Of Chemistry Faculty Of Sciences Kyushu Uni

• Shimohigashi Yasuyuki

  Laboratory Of Structure-function Biochemistry Department Of Chemistry Faculty Of Sciences Kyushu Uni

• ISHIDA Toshimasa

  Department of Pyysical Chemistry, Osaka University of Pharmaceutical Sciences

• MINOURA Katsuhiko

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• KISHIMA Shouitirou

  Department of Physical Chemistry, Osaka University of Pharmaceutical Sciences

• Ishida T

  Osaka Univ. Pharmaceutical Sci. Osaka

• Ishida Toshimasa

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Nose Takeru

  Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University

• Shimohigashi Yasuyuki

  Laboratory Of Structure-function Biochemistry Department Of Molecular Chemistry Graduate School Of S

• Kishima Shouitirou

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Ishida T

  Departments Of Biochemistry Shiga University Of Medical Science

• Minoura K

  Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences

• Inamori Yoshihiko

  Osaka College Of Pharmacy

• Ishida Toshimasa

  Dep. Of Physical Chemistry Osaka Univ. Of Pharmaceutical Sciences

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