Crystal and Molecular Structure of an (S)-(+)-Enantiomer of Modafinil, a Novel Wake-Promoting Agent
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概要
- 論文の詳細を見る
The (+)-enantiomer of modafinil [(RS)-2-(diphenylmethylsulfinyl)acetamide], a novel wake-promoting agent, was clarified to be S-configuration by X-ray crystal structure analysis. The crystal consists of two crystallographically independent conformers that are different at the torsion angles around the sulfinylacetamide moiety, and this results from the molecular packing requirement to form a two-dimensional hydrogen-bonding network via neighboring amide groups in the crystal. The crystal structure is characterized by the formation of alternative hydrophobic and hydrophilic layers, which are formed among the symmetry-translated assemblies of diphenylmethyl and sulfinylacetamide moieties, respectively. The spatial orientation between the diphenyl and amide groups is believed to be important for the activity of modafinil.
- 2004-10-01
著者
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石田 尚行
電気通信大量子物質工
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IN Yasuko
Osaka University of Pharmaceutical Sciences
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ISHIDA Toshimasa
Osaka University of Pharmaceutical Sciences
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In Y
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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In Yasuko
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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TOMOO Koji
Department of Pyysical Chemistry, Osaka University of Pharmaceutical Sciences
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ISHIDA Toshimasa
Department of Pyysical Chemistry, Osaka University of Pharmaceutical Sciences
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Ishida Toshimasa
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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TOMOO Koji
Osaka University of Pharmaceutical Sciences
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Koji Tomoo
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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Tomoo Koji
Department Of Physical Chemistry Osaka University Of Pharmaceutical Sciences
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Iwashita T
Suntory Institute For Bioorganic Research
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Ishida T
Departments Of Biochemistry Shiga University Of Medical Science
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SAKAMOTO Yasuhiko
Research & Development Division, AZWELL, Inc.
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Sakamoto Yasuhiko
Research & Development Division Azwell Inc.
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Inamori Yoshihiko
Osaka College Of Pharmacy
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Ishida Toshimasa
Dep. Of Physical Chemistry Osaka Univ. Of Pharmaceutical Sciences
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