Biological Activity of 4-Acetyltropolone, the Minor Component of Thujopsis dolabrata SIEB. et ZUCC. hondai MAK.

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概要

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• 4-Acetyltropolone, a minor component of Thujopsis dolabrata SIEB. et ZUCC. hondai MAKINO, showed antimicrobial activity against various microorganisms including wood-rotting fungi, a phytogrowth-inhibitory effect with chlorophyll biosynthesis inhibition, cytotoxic effect and inhibitory activity on metalloproteases. This compound had strong antifungal activity on Daedalea dickinsii IFO-4979 [minimum inhibitory concentration (MIC):0.2μg/ml] and Coriolus versicolor IFO-4940 (MIC: 0.39μg/ml). Its cytotoxic effect at 20.0 μg/ml on human stomach cancer KATO-III and Ehrich's ascites carcinoma was stronger than those of podophyllotoxin, vincristine and vinblastine, the anticancer agents isolated from higher plants and used clinically. This compound also had potent antibacterial activity against Staphylococcus epidermidis IFO-12993, its MIC being 1.56μg/ml. However, other biological activities of 4-acetyltropolone were lower than those of hinokitiol which is the main component of this plant, suggesting that the contribution of the acetyl group at C-4 to biological activity is smaller than that of the isopropyl group at that position. The acute toxicity of 4-acetyltropolone (LD_<50>: 335.2 mg/kg) to mice was much lower than that of hinokitiol (LD_<50>: 191 mg/kg).

• 公益社団法人日本薬学会の論文
• 2002-08-01

著者

• Matsumura E

  Osaka University Of Pharmaceutical Sciences

• Matsumura Eiko

  Osaka University Of Pharmaceutical Sciences

• Inamori Yoshihiko

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• IN Yasuko

  Osaka University of Pharmaceutical Sciences

• In Y

  Osaka Univ. Pharmaceutical Sci. Osaka Jpn

• Morita Y

  Osaka Organic Chemical Industry Ltd.

• TSUJIBO Hiroshi

  Osaka University of Pharmaceutical Sciences

• INAMORI Yoshihiko

  Osaka University of Pharmaceutical Sciences

• Okabe Toshihiro

  Department Of Surgery Tokyo Women's Medical University Daini Hospital

• OKABE Toshihiro

  Industrial Research Institute of Aomori Prefecture

• Morita Yasuhiro

  Osaka Organic Chemical Industry Ltd

• YASUDA Masahide

  Osaka University of Pharmaceutical Sciences

• OKABE TOSHIHIRO

  Aomori Industrial Research Center

• OHE TATSUHIKO

  Osaka Manicipal Research Institute

• ISHIDA NAKAO

  The Sendai Institute of Microbiology

• TSUJIBO Hiroshi

  Department of Microbiology, Osaka University of Pharmaceutical Sciences

• AKAGAMI Yoshikazu

  Osaka Prefectural Institute of Public Health

• KUMEDA Yuko

  Osaka Prefectural Institute of Public Health

• Okabe T

  Aomori Industrial Research Center

• Ishida N

  The Sendai Institute Of Microbiology

• Okabe Toshihiro

  Department Of Endocrine Surgery Tokyo Women's Medical University

• Miki Y

  Kinki Univ. Higashi‐osaka Jpn

• Yoshimura M

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Yasuda Masahide

  Osaka College Of Pharmacy

• Tsujibo H

  Department Of Microbiology Osaka University Of Pharmaceutical Sciences

• Inamori Yoshihiko

  Osaka College Of Pharmacy

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