Biological Activity of β-Dolabrin, γ-Thujaplicin, and 4-Acetyltropolone, Hinokitiol-Related Compounds(Biochemistry/Molecular Biology)
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概要
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β-Dolabrin, γ-thujaplicin, and 4-acetyltropolone, the components of Aomori Hiba (Thujopsis dolabrata SIEB. et Zucc. van hondai MAKINO), showed antifungal activity on seven kinds of plant-pathogenic fungi, antibacterial activity against two kinds of Legionella sp., and in vitro cytotoxic effect on murine P388 lymphocytic leukemia cell line. Firstly, β-dolabrin, γ-thujaplicin and 4-acetyltropolone had clear antifungal activity against seven kinds of plant-pathogenic fungi tested. In particular, β-dolabrin and 4-acetyltropolone showed strong antifungal activity against Pythium aphanidermatum IFO 32440, with minimum inhibitory concentration (MIC) values of 6.0μg/ml. Secondly, β-dolabrin, γ-thujaplicin and 4-acetyltropolone had obvious growth-inhibitory effect on two kinds of Legionella sp. 4-Acetyltropolone especially had strong antibacterial activity toward Legionella pneumophila SG 1, and its MIC value was 3.1μg/ml. These three compounds showed cytotoxic effects against murine P388 lymphocytic leukemia cell line in vitro. The cytotoxic effect of three compounds in the murine P388 lymphocytic leukemia cell line were clear when cell growth was measured using the 3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide (MTT) method. At 48 h after treatment, γ-thujaplicin and 4-acetyltropolone at 0.63μg/ml inhibited cell growth of murine P388 lymphocytic leukemia by 85% and 65%, respectively. At the same time after treatment, the growth of the murine P388 lymphocytic leukemia cell line was completely suppressed by the three compounds at concentrations higher than 5.0μg/ml. Among these three compounds, γ-thujaplicin had the strongest cytotoxic activity on the growth of this tumor cell line in vitro.
- 公益社団法人日本薬学会の論文
- 2004-10-01
著者
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Matsumura E
Osaka University Of Pharmaceutical Sciences
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Matsumura Eiko
Osaka University Of Pharmaceutical Sciences
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Inamori Yoshihiko
Department Of Microbiology Osaka University Of Pharmaceutical Sciences
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Morita Y
Osaka Organic Chemical Industry Ltd.
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INAMORI Yoshihiko
Osaka University of Pharmaceutical Sciences
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Fukui T
Hoshi Univ. Tokyo Jpn
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Fukui T
Byotai‐seiri Lab. Tokyo Jpn
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Okabe Toshihiro
Department Of Surgery Tokyo Women's Medical University Daini Hospital
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Morita Yasuhiro
Osaka Organic Chemical Industry Ltd
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OKABE TOSHIHIRO
Aomori Industrial Research Center
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OHE TATSUHIKO
Osaka Manicipal Research Institute
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ISHIDA NAKAO
The Sendai Institute of Microbiology
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FUKUI Toru
Byotai-Seiri Laboratory
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ISHIDA Nakao
Sendai Institute of Microbiology
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Okabe T
Aomori Industrial Research Center
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Ishida N
The Sendai Institute Of Microbiology
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Fukui T
Byotai-seiri Laboratory
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Okabe Toshihiro
Department Of Endocrine Surgery Tokyo Women's Medical University
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Miki Y
Kinki Univ. Higashi‐osaka Jpn
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Fukui T
Department Of Materials Science And Engineering Faculty Of Engineering Kyushu University
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Inamori Yoshihiko
Osaka College Of Pharmacy
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FUKUI Toru
Byotai Seiri Laboratory
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