Induction of Apoptosis in the Human Promyelocytic Leukemia Cell Line HL60 by Falconensone A and Its Derivatives, New Polyenes
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概要
- 論文の詳細を見る
Falconensones A and B are a new type of yellow pigment with structural similarity to retinoic acid isolated from the mycelial extract of ascomycetous fungi, Emericella falconensis or Emericella fruticulosa. In the present study we show that falconensone A alone induced apoptosis of HL60 human leukemia cells, while falconensone B, the 4'-nor-methyl derivative of falconensone A, had much lower activity. The synthetic derivatives of falconensone A, falconensone A p-bromophenylhydrazone and falconensone A dioxime, were more potent than natural falconensone A and B as far as the induction of apoptosis was concerned. The induction of apoptosis by the falconensones correlated with their inhibition of cell growth. In addition, falconensones A and B, and falconensone A dioxime, increased the generation of intracellular reactive oxygen species, while falconensone A p-bromophenylhydrazone was inactive. These results suggest that falconensone A, falconensone A p-bromophenylhydrazone and falconensone A dioxime are potential new apoptosis-inducing agent. The enhanced generation of reactive oxygen species in cells may be involved in apoptosis induced by falconensone A and falconensone A dioxime, but not by falconensone A p-bromophenylhydrazone. It is also suggested that the methyl residue at the 4' position of the falconensone A cyclopentenone ring may be essential for the induction of apoptosis. Based on these results, falconensone A and its derivatives may be clinically useful in the treatment of some leukemias.
- 公益社団法人日本薬学会の論文
- 2000-06-01
著者
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Takahashi Noriko
星薬科大学医薬品化学研究所 病態機能制御学研究室
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Takahashi N
Faculty Of Pharmaceutical Sciences Hoshi University
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Takahashi Noriko
Faculty Of Pharmaceutical Sciences Hoshi University
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Takahashi Noriko
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences Core Research Fo
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Takahashi N
Laboratory Of Physiological Chemistry Institute Of Medicinal Chemistry Hoshi University
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IWAHORI Akiyo
Department of Health Chemistry, Hoshi University
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FUKUI Tetsuya
Department of Health Chemistry, Hoshi University
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Kawai Ken-ichi
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Iwahori A
Hoshi Univ. Tokyo Jpn
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Iwahori Akiyo
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Fukui T
Hoshi Univ. Tokyo Jpn
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Fukui T
Byotai‐seiri Lab. Tokyo Jpn
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Fukui Tetsuya
Department Of Health Chemistry
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Fukui Tetsuya
Hoshi University
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KUBO Yoshinori
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
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KUBO Yoshinori
Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University
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Kawai K
Faculty Of Pharmaceutical Sciences Meijo University
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Fukui T
Byotai-seiri Laboratory
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Kubo Yoshinori
Laboratory Of Physiological Chemistry Institute Of Medicinal Chemistry Hoshi University
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Kubo Yoshinori
Department Of Health Chemistry Hoshi University
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Fukui T
Department Of Materials Science And Engineering Faculty Of Engineering Kyushu University
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