Effect of Human Placenta Extract on Potassium Oxonate-Induced Elevation of Blood Uric Acid Concentration
スポンサーリンク
概要
- 論文の詳細を見る
Although anti-inflammatory effect of human placenta extract (HPE) was observed in rheumatoid arthritis and carrageenin-induced edema, effect of HPE on the arthritis of hyperuricemia and gout patients had never been examined. Excess uric acid is regarded to be a major risk factor in gout, renal diseases, cardiovascular diseases and cerebrovascular diseases. In our experiment, in order to investigate the effect of HPE on blood uric acid levels and xanthine oxidase (XO) activity, HPE 100 mg/kg was administered to the abdominal cavity of potassium oxonate-induced hyperuricemic mice. Blood uric acid levels and XO activity were measured 3 hr after administration. Furthermore, effect of HPE on in vitro superoxide anion generation in xanthine-XO system was also measured. In experimental mice, oxonate-induced significant elevation of blood uric acid levels was suppressed by the HPE administration similar to the allopurinol administration. Similarly, both in HPE-treated mice and in allopurinol-treated mice, blood XO activity was significantly reduced in comparison with vehicle-treated mice and oxonate-treated mice. Furthermore, there was significant positive correlation between blood uric acid levels and XO activity (p<0.01). In in vitro experiments, xanthine concentration was increased by the addition of HPE while simultaneously reducing uric acid concentration. These results indicate that HPE contains some XO inhibitors which reduce blood uric acid levels with inhibiting uric acid generation in purine metabolism. Then, XO inhibitors of HPE could be used in the treatment of hyperuricemia and gout patients to lower blood uric acid levels.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
-
渡辺 聡
星薬科大学衛生化学教室
-
WATANABE Satoshi
Department of Rehabilitation Medicine, St. Marianna University Hospital
-
Watanabe Satoshi
星薬科大学 薬学部衛生化学
-
渡辺 聡
星薬大・薬
-
Watanabe Satoshi
Aono Atomcraft Project Erato Research Development Corporation
-
Watanabe Satoshi
Faculty Of Pharmaceutical Sciences Hoshi University
-
Watanabe Satoshi
Hoshi University
-
Watanabe Satoshi
Department Of Agricultural Chemistry University Of Tokyo
-
Watanabe Satoshi
Advanced Research Laboratory Hitachi Ltd.
-
渡辺 聡
星薬大
-
FUKUI Tetsuya
Department of Health Chemistry, Hoshi University
-
Fukui Tetsuya
Department Of Health Chemistry
-
KIMURA Yumi
Department of Oral Radiology, School of Dental Medicine, Tsurumi University
-
Watanabe S
Hoshi Univ. Tokyo Jpn
-
Kimura Yumi
Department Of Field Medicine School Of Public Health
-
Kimura Yumi
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
-
Shindo Kaoru
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
-
Shindo Kaoru
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
関連論文
- 臭素酸カリウムと還元型グルタチオンによるリノール酸の過酸化に対する酢酸レチノールの抑制効果
- Peak time of acute coronary syndrome in patients with sleep disordered breathing
- PJ-810 Evaluation of Exercise-Induced Mitral Regurgitation Mechanism in Patients with Left Ventricular Dysfunction Using Transthoracic 3D-Echocardiography(PJ136,Echo/Doppler (Others) 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of Th
- DPJ-049 Effect of Exercise-Induced Mitral Regurgitation Changes on Exercise Capacity in Patients with Chronic Heart Failure(DPJ09,Exercise Test/Cardiac Rehabilitation (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-861 The Influence of Dynamic Ventricular Dyssynchrony on Exercise Capacity in Patients with Chronic Heart Failure(Echo / Doppler(18)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-857 Relationship between QRS Complex and Intraventricular Mechanical Synchronicity in Patients with Chronic Heart Failure by Real-Time Three-Dimensional Echocardiography(Echo / Doppler(18)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting
- PJ-501 Relationship between breathing pattern on effort and sleep disordered breathing(SDB) in patients with chronic heart failure(CHF)(Exercise test/Cardiac rehabilitation(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
- PJ-304 The Influence of Left Ventricular Diastolic Pressure on Pulmonary Artery Pressure During Exercise in Patients with Chronic Heart Failure(Exercise test/Cardiac rehabilitation(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the
- PJ-302 Predictors of exercise capacity in patients with chronic heart failure(Exercise test/Cardiac rehabilitation(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Strain difference in tolerance to low-temperature treatment of fertilized mouse oocytes
- PJ-810 Evaluation of Exercise-Induced Mitral Regurgitation Mechanism in Patients with Left Ventricular Dysfunction Using Transthoracic 3D-Echocardiography(PJ136,Echo/Doppler (Others) 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of Th
- DPJ-049 Effect of Exercise-Induced Mitral Regurgitation Changes on Exercise Capacity in Patients with Chronic Heart Failure(DPJ09,Exercise Test/Cardiac Rehabilitation (H),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-857 Relationship between QRS Complex and Intraventricular Mechanical Synchronicity in Patients with Chronic Heart Failure by Real-Time Three-Dimensional Echocardiography(Echo / Doppler(18)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting
- PJ-501 Relationship between breathing pattern on effort and sleep disordered breathing(SDB) in patients with chronic heart failure(CHF)(Exercise test/Cardiac rehabilitation(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
- PJ-304 The Influence of Left Ventricular Diastolic Pressure on Pulmonary Artery Pressure During Exercise in Patients with Chronic Heart Failure(Exercise test/Cardiac rehabilitation(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the
- Relationship Between Sleep-Disordered Breathing Level and Acute Onset Time of Congestive Heart Failure
- 脂質ラジカルに対する消化性潰瘍治療剤の消去作用について
- グルタチオンラジカルによる脂質過酸化に対する酢酸レチノールの抑制作用
- 一枚膜リポソームを用いたクルクミンの抗酸化作用の検討
- 臭素酸カリウムの毒性学的研究(第2報)臭素酸カリウムとベンゾ[a]ピレン併用投与時における肝障害の検討
- 臭素酸カリウムの毒性学的研究(第1報)臭素酸カリウムのラットにおける吸収, 代謝, 排泄
- ビタミンC強化食摂餌による臭素酸カリウムの毒性軽減効果
- 臭素酸カリウムの毒性学的研究(第3報)臭素酸カリウム投与時におけるビタミンEの効果
- マウスの急性アルコール性肝障害に対するフラビンアデニンジヌクレオチドの抑制機構の検討
- PJ-137 Relationship between the blood pressure level and sleep apnea syndrome(Hypertension, clinical(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-134 Impact of continuous positive airway pressure therapy on metabolic syndrome in patients with obstructive sleep apnea syndrome(Hypertension, clinical(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- トリクロロ酢酸及びトリクロロエチレンによるマウスの脂質過酸化反応と肝障害
- ペンタクロロフェノールによる脂質過酸化反応に対するリボフラビン酪酸エステルの抑制効果
- トリクロロエチレンおよびトリクロロ酢酸による肝障害に対するフラビンアデニンジヌクレオチドの抑制効果
- トリクロロ酢酸のIn Vitro代謝に伴う脂質過酸化反応に対するフラビン誘導体の抑制効果
- 1-III-10 トリクロロエチレンの代謝に伴うマウス肝臓の脂質過酸化反応に対するFADの抑制効果 : 第46回大会研究発表要旨
- ミクロゾームでのエタノールの代謝による脂質過酸化反応に対するフラビンアデニンジヌクレオチドの抑制効果
- ペンタクロロフェノールの代謝に伴う活性酸素種の発生と脂質過酸化反応
- 臭素酸カリウムと還元型グルタチオンの反応による活性酸素種の発生と脂質過酸化反応
- マウスの急性アルコール性肝障害に対するフラビンアデニンジヌクレオチドの抑制効果
- ミセル状リノール酸の過酸化反応に対するリボフラビンの抑制作用の酸素電極法による検討
- In vitro反応系におけるチオバルビツール酸反応性物質生成に対するリボフラビンの抑制効果
- 26pPSB-58 MD simulations of heat transport in carbon nano-structures under non-reflecting boundary conditions
- Effect of Acidosis on Apoptosis and Necrosis Induced by Hypoxia in Neuronal Cells
- Repulsion-Induced Order Formation in Graphite-Diamondlike Transition of Boron Nitride : A Molecular Dynamics Study (Condensed Matter: Structure, Mechanical and Thermal Properties)
- Multistage Order-Disorder Surface Transition of Si(111)√3×√3-Ag Surface with Defects(Condensed Matter : Structure, Mechanical and Thermal Properties)
- Multistage Order-Disorder Surface Transition of Si(111)√×√-Ag Surface with Defects
- Epitaxial Growth of Cubic BN on Diamond : An Ab Initio Study
- Migration-Enhanced Epitaxy of Cubic BN : An Ab Initio Study
- Effects of Anion Channel Blockers on Xylem Nitrate Transport in Barley Seedlings
- Apoptosis of Mouse Pancreatic Acinar Cells after Duct Ligation
- PIVKA-II-producing advanced gastric cancer
- Resection of Liver Metastasis from Alpha-Fetoprotein-Producing Early Gastric Cancer: Report of a Case
- Pioglitazone Reduces the Necrotic-Core Component in Coronary Plaque in Association With Enhanced Plasma Adiponectin in Patients With Type 2 Diabetes Mellitus(Ischemic Heart Disease)
- PJ-181 Impact of Sleep-disordered Breathing on the Exercise Training Effect in Patients with Myocardial Infarction(Exercise test/Cardiac rehabilitation-4 (IHD) PJ31,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese C
- PJ-075 The Relationship between Myocardial Hypertrophy in Obstructive Sleep Apnea Syndrome(Hypertension, clinical-10 (H) PJ13,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-058 The Relationship between Reverse Remodelling and Sleep Apnea Syndrome(Heart failure, clinical-18 (M) PJ10,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-054 The Training Effects of Skeletal Muscle Strength and Muscle Volume to Improve Functional Capacity in Heart Failure Patients(Heart failure, clinical-17 (M) PJ9,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
- PJ-037 The Impact of Skeletal Muscle Strength and Volume on the Improvement of Functional Capacity in Patients with Postoperative Heart Disease(Exercise test/Cardiac rehabilitation-5 (IHD) PJ7,Poster Session (Japanese),The 70th Anniversary Annual Scientif
- OJ-051 The Relationship between Adiponectin Affecting to Body Composition, Skeletal Muscle Strength and Functional Capacity in Heart Failure Patients(Heart failure, clinical-2 (M) OJ9,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Mee
- OE-163 The Relationship between the Severity of Sleep Apnea Syndrome and Risk of Cardiovascular Events in Chronic Heart Failure Patients(Heart failure, clinical-1 (M) OE28,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the J
- Effect of Exercise Training on Skeletal Muscle Volume in Cardiac Patients (Exercise Test/Cardiac Rehabilitation 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Relationship between Sleep Apnea Syndrome and Blood Pressure Control(Hypertension, Clinical 9 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Predictors of Peak Oxygen Uptake in Patients with Chronic Heart Failure(Heart Failure, Clinical 8 (M) The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Impact of Skeletal Muscle Strength and Muscle Volume on the Improvement of Functional Capacity in Cardiac Patients(Exercise Test/Cardiac Rehabilitation 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Relationship between H. pylori Seropositivity and Exercise Capacity in Heart Failure Patients(Exercise Test/Cardiac Rehabilitation 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Relationship between Sleep Apnea Syndrome and the Onset Time of Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Pathophysiology) 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Relationship between Sleep-disordered Breathing Level and Acute Occurrence Time of Congestive Heart Failure(Sleep Apnea and Cardiovascular Disease (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Association between Oscillatory Ventilation during Exercise and Central Sleep Apnea in Patients with Chronic Heart Failure(Exercise Training and Cardiac Rehabilitation (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-451 Physical activity, Self-efficasy, and health-related quality of life outcomes 1 and 3 year after onset of acute myocardial infarction(Preventive Medicine/Epidemiology/Education 4 (H) : PJ75)(Poster Session (Japanese))
- PE-379 Effect of self-monitoring during cardiac rehabilitation on exercise maintenance, self-efficacy, and physical activity after acute myocardial infarction(Exercise Test/Cardiac Rehabilitation 7 (IHD) : PE65)(Poster Session (English))
- Acellular Calcified Columns in the Normal Growth Plate of Mouse Vertebrae
- The Effects of Unsupervised Exercise Training on Physical Activity and Physiological Factors after Supervised Cardiac Rehabilitation
- A New, Simple Stapling Technique for Pulmonary Emphysema : Its Effects and Safety for Improving Respiratory Function
- Effect of Monosilicate, Phosphate, and Carbonate on Iron Dissolution by Mugineic Acid
- PJ-118 Comparison of peak oxygen uptake and brain natriuretic peptide (BNP) to predict prognosis in patients with heart failure(Heart failure, clinical(13)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-082 The influence of nocturnal blood pressure on left ventricular diastolic function in patients with obstructive sleep apnea syndrome(Echo/Doppler(11)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-081 The impact of nocturnal blood pressure reduction on left ventricular diastolic function in obstructive sleep apnea syndrome patients(Echo/Doppler(11)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- PE-548 Relationship Between Nocturnal Blood Pressure Pattern and Left Ventricular Hypertrophy in Patients with Sleep Apnea Syndrome(Hypertension, clinical(06)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Societ
- PE-547 The Influence of Obesity on Blood Pressure and Left Ventricular Hypertrophy in Patients with Sleep Apnea Syndrome(Hypertension, clinical(06)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-420 Comparison of peak oxygen uptake and VE/VCO2 slope to predict prognosis in patients with heart failure(Exercise test/Cardiac rehabilitation(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-419 The identification of high risks in heart failure patients with low brain natriuretic peptide by cardiopulmonary exercise testing(Exercise test/Cardiac rehabilitation(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
- PE-418 The Relationship Between Cardiac Function During Exercise and Sleep Disordered Breathing in Patients with Chronic Heart Failure(Exercise test/Cardiac rehabilitation(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese C
- P484 INFLUENCE OF ADAPTIVE REMODELING ON RESTENOSIS FOLLOWING ANGIOPLASTY
- P246 LIMITATIONS OF PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY (PTCA) WITH REFERENCE TO QUALITY OF LIFE(QOL) ON ANGINA PECTORIS : ASESSMENT BY MULTIVARIATE ANALYSIS
- Multiplet Structures of Transition Metal Deep Impurities in ZnS
- Effect of Antioxidant on Trichloroethylene-induced Liver Cell Injury and Peroxisome Proliferation (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- On the Deflation Algorithm for MultipleRoots of Systems of Nonlinear Algebraic Equationsand the Order of Convergence
- Hybrid Manipulations for the Solution of Systems of Nonlinear Algebraic Equations
- PE-382 The influence of age on intima-media thickness in patients with sleep apnea syndrome(Atherosclerosis, clinical(07)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- L-Tryptophan as an Antioxidant in Human Placenta Extract
- Suppressive Effects of Uracil, Tyrosine, and Phenylalanine Contained in Human-Placenta Extract on Acute Ethanol-Induced Liver Injury in Mice
- Purification and Identification of Antioxidant Substances in Human-Placenta Extracts
- Studies on the Suppressive Effect of Antioxidant in Human Placental Extract on Oxidative Stress and its Mechanism(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Theoretical Analysis of Apparent Barrier Height on an Al Surface : Difference by Measurement Methods
- First-Principles Study of Apparent Barrier Height : Surfaces, Interfaces, and Films
- Ab Initio Calculation of the Electric Properties of Al Atomic Chains under Finite Bias Voltages : Electronical Properties of Condensed Matter
- Novel Biological Activity of the Region (106-126) on Human Prion Sequence
- Contribution of Nitric Oxide to Potassium Bromate-Induced Elevation of Methaemoglobin Concentration in Mouse Blood(Toxicology)
- Potassium Bromate-lnduced Hyperuricemia Stimulates Acute Kidney Damage and Oxidative Stress
- Effect of Human Placenta Extract on Potassium Oxonate-Induced Elevation of Blood Uric Acid Concentration
- Experimental Study of Stall Behavior in Radial Vaneless Diffuser of Centrifugal Pump
- Development of Pulsatile Flow Experiment System and PIV Measurement in an Elastic Tube
- Suppressive Effect of Curcumin on Trichloroethylene-induced Oxidative Stress
- Lipid Radical-Scavenging Effect of Antiulceratives