Novel Biological Activity of the Region (106-126) on Human Prion Sequence
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概要
- 論文の詳細を見る
We report that the synthetic peptide Prp106-126 (KTNMKHMAGAAAAGAVVGGLG-COOH) and the reversed peptide Prp126-106 (GLGGVVAGAAAAGAMHKMNTK-COOH) of human prion (hPrp) can express the decarboxylase activity for oxaloacetate in the presence of trifluoroethanol, similar to that of Oxaldie 1 (LAKLLKALAKLLKK-CONH_2) reported previously. The degree of the relative activity of Prp106-126 and Prp126-106 to Oxaldie 1 is 0.47 and 0.21, respectively. Based on this experimental result, we applied the informational system method (ISM) developed by Veljkovic et al. to the amino acid sequence of Prp106-126 and Prp126-106 to extract a common factor. The same spectra were obtained, indicating that the same periodicity may be conserved on their sequences, as a necessary factor for expressing the same biological activity, irrespective of the orientation of the primary sequence.
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
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渡辺 聡
星薬科大学衛生化学教室
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Watanabe Satoshi
星薬科大学 薬学部衛生化学
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渡辺 聡
星薬大・薬
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Watanabe Satoshi
Aono Atomcraft Project Erato Research Development Corporation
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Watanabe Satoshi
Faculty Of Pharmaceutical Sciences Hoshi University
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Watanabe Satoshi
Hoshi University
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Watanabe Satoshi
Advanced Research Laboratory Hitachi Ltd.
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渡辺 聡
星薬大
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Fukui T
Hoshi Univ. Tokyo Jpn
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Fukui Tetsuya
Hoshi University
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NUMAO Naganori
BioFrontier Institute Inc.
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KOBAYASHI Susumu
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Yamazaki Akiko
Department Of Earth Science School Of Education Waseda University
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Yamazaki Akiko
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Noguchi Norihisa
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Noguchi Norihisa
Tokyo University Of Pharmacy And Life Science
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Kobayashi Susumu
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kobayashi Susumu
Department Of Pharmaceutical Sciences Tokyo University Of Science
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Watanabe S
Hoshi Univ. Tokyo Jpn
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Watanabe S
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Numao N
Biofrontier Institute Inc.
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Numao Naganori
Biofrontier Inst. Inc.
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Kobayashi S
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat
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EGUCHI Yukihiro
Mitsui Knowledge Industry Co., Ltd.
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KAMINO Tomoyuki
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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SHIMOZONO Noriko
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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SASATSU Masanori
Tokyo University of Pharmacy and Life Science
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Sasatsu M
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Kamino Tomoyuki
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Eguchi Y
Mitsui Knowledge Industry Co. Ltd.
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Numao N
Biofrontier Inst. Inc.
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Shimozono Noriko
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Sasatsu Masanori
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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