A Fourth Scale Sensitive to the Magnetic Field; Intermolecular Frequency Symmetry in a Specific Interaction between Protein and Low-Molecular Compound
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概要
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We found a new method that a specific interaction between prion, i.e., high-molecular compound, and Cp-60, i.e., low-molecular one, could be successfully elucidated with intermolecular frequency symmetry (IFS). To accomplish this, the former sequence is analyzed with a sequence Fourier analysis used average nuclear (N) resonant frequency scale as a fourth one, and the latter structure with a 13C-NMR software. Further, such the symmetry could be observed in a specific interaction between a segment of human immunodeficiency virus (HIV)gag and PA-457 or between 1918 neuraminidase and peramivir. Therefore, the IFS rule seems to be evolutionarily conserved as a necessary condition even in a specific protein-organic compound interaction.
- 公益社団法人 日本薬学会の論文
著者
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Fukui Tetsuya
Hoshi University
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NUMAO Naganori
BioFrontier Institute Inc.
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FUKAZAWA Yoshiyuki
Kanagawa Industrial Technology Research Institute
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Numao Naganori
Biofrontier Inst. Inc.
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Fukazawa Yoshiyuki
Kanagawa Industrial Technology Center
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