Hydrophobic Scale : a Second Parameter to Elucidating Various Specific Ligand-Protein Interactions
スポンサーリンク
概要
- 論文の詳細を見る
In the sequence Fourier analysis (SFA) of specific interactions such as those between fibroblast growth factors (FGFs)/FGF receptors (FGFRs), bone morphogenetic proteins (BMPs)/BMP receptors (BMPRs), or tumor represser protein p53/mouse double minute 2 homolog (MDM2), the characteristic frequency peak(s) could be observed with the hydrophobic scale for 20 amino acids as well as 4 nucleotides as the physicochemical parameter, but not successfully with the absolute electronegativity scale. This result implies that these two independent scales should be appropriately selected in various specific ligand-protein interactions, though the critical difference has to be determined.
- 社団法人日本薬学会の論文
- 2004-03-01
著者
-
Tanaka Kazuyoshi
Department of Biofunctional Informatics, Graduate School of Health Care Sciences, Tokyo Medical and
-
Tanaka K
Department Of Molecular Engineering Graduate School Of Engineering Kyoto University
-
Fujii Hiroko
Faculty Of Pharmaceutical Sciences Fukitoka University
-
Tanaka Ken-ichiro
Faculty Of Pharmaceutical Sciences Okayama University
-
NUMAO Naganori
BioFrontier Institute Inc.
-
FUJII Hisashi
Kanagawa Industrial Technology Research Institute
-
FUKAZAWA Yoshiyuki
Kanagawa Industrial Technology Research Institute
-
HANAGATA Nobutaka
Tokyo University of Technology
-
Hanagata Nobutaka
Nanotechnology Innovation Center, National Institute for Materials Science
-
Tanaka Katsuyuki
Dept. Biol. Sci. Fac. Sci. Hiroshima Univ.
-
Hanagata Nobutaka
Nanotechnology Innovation Center National Institute For Materials Science
-
Hanagata Nobutaka
Research Center For Advanced Science And Technology University Of Tokyo
-
Hanagata Nobutaka
Research Center For Advanced Science And Technology The University Of Tokyo
-
Numao N
Biofrontier Institute Inc.
-
Numao Naganori
Biofrontier Inst. Inc.
-
Tanaka K
Dept. Biol. Sci. Fac. Sci. Hiroshima Univ.
-
Fujii H
Kanagawa Industrial Technology Research Institute
-
Hanagata N
Research Center For Advanced Science And Technology The University Of Tokyo
-
Hanagata N
Tokyo University Of Technology
-
Numao N
Biofrontier Inst. Inc.
-
Tanaka Kazuyoshi
Department Of Biofunctional Informatics Graduate School Of Health Care Sciences Tokyo Medical And De
-
Fujii Hisashi
Kanagawa Industrial Technology Center
-
Fukazawa Yoshiyuki
Kanagawa Industrial Technology Center
関連論文
- Ultrasonic anisotropy measured in 2-dimensional echocardiograms in vitro and verified by histology
- Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XIV. Inhibitory Effect of Carboxamide-Methylated Light Chain (G_1L) on Tyrosine Phosphorylation and Tumor Necrosis Factor-α Production from Murine Macrophages Stimulated by
- Induction of Unresponsiveness of Antigen-Specific T Lymphocytes by Oral Administration of Cedar Pollen Extract in Mice
- Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. XIII. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) on Type II Collagen-Induced Arthritis in DBA/1J Mice
- Abnormal Accumulation of Copper-Metallothionein in the Liver and Kidney of Long-Evans Rats with a Cinnamon-Like Coat Color (LEC Rats)
- Serum Hepatocyte Growth Factor Activity and Hepatocyte Proliferation in Long-Evans with a Cinnamon-Like Coat Color Rats with Hepatic Lesions
- Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. XII. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) from Human Immunoglobulin G on Mixed Lymphocyte Reaction
- Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XI. Increment of Tumor Necrosis Factor (TNF) Activity in Mouse Sera by Carboxamide-Methylated Light Chain
- Studies on Thermophile Products. VI. Activation of Mouse Peritoneal Macrophages by Bis(2-hydroxyethyl) Trisulfide
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G by Chemical Modification and Active Subfragments. IX. Anti-inflammatory Activity of Completely Alkylated Heavy Chain (C.Fr.I-H)
- Synthesis and Structures of Highly Conducting Charge-Transfer Salts of Selenium Containing TTM-TTP Derivatives
- Synthesis and Structures of Neutral Crystals and Charge-Transfer Salts of Selenium Containing TMET-TTP Derivatives
- Preparation and Characterization of Novel Aromatic-inserted Tris-fused Tetrathiafulvalenes
- Microscopic Investigation of a New Two-Component Organic Conductor with Itinerant and Localized Spins : (CHTM-TTP)_2TCNQ
- Dimerization Effect on the Physical Properties in New One-Dimensional Organic Conductors: (ChTM-TTP)_2AuBr_2, (ChTM-TTP)_2GaCl_4, and (ChTM-TTP)ReO_4
- A Novel Organic Conductor with Two-Dimensional Molecular Array by the "Edge-to-Edge" Donor Interaction
- Marginal Paramagnetic State of a One-Dimensional Half-Filled Alternating Chain in (TTM-TTP) AuI_2 : Condensed Matter: Electronic Properties, etc.
- A Novel Organic Conductor with Three-Dimensional Molecular Array: (TM-TPDS)_2AsF_6
- ESR Investigation of Organic Conductors (DTM-TTP)(TCNQ)(TCE) and (TMET-TTP)_2(TCNQ) : Condensed Matter: Electronic Properties, etc.
- Raman Investigation of the One-Dimensional Organic Conductor with a Half-Filled Band,(TTM-TTP) I_3
- Structures and Properties of (TMEO-ST-TTP)_2AsF_6
- Novel One-Dimensinal Organic Conductor Based On Selenium-Containing Bis-Fused Tetrathiafulvalene Derivative, (TSM-TTP)(I_3)5/3
- Structure and Properties of (DTM-TTP)(TCNQ)(TCE) and the Related Complex
- Pharmacological Activity of Chemically Modified Subfragment from Human Serum IgG. XIV. Inhibitory Effect of Carboxamide-Methylated Light Chain (G_1L) on Tyrosine Phosphorylation and Tumor Necrosis Factor-α Production from Murine Macrophages Stimulated by
- Preparation of Biologically Active and Site Specifically Radioiodinated Recombinant Human Insulin-like Growth Factor-I
- Inhibitory Effects of Bis(2-aminohexyl)disulfide and Its Analogues on Polymorphonuclear Leukocyte Functions in Vitro
- ISOLATION OF A NEW ANTITUMOR SUBSTANCE FROM BACILLUS STEAROTHERMOPHILUS
- The Effect of a Cystamine Derivative, Bis[2-(E-2-hexenoylamino)ethyl] Disulfide, on Rat Platelet Aggregation
- Hepatoprotective Effect of Combretum quadrangulare and Its Constitutents
- Effect of culture conditions on morphological changes of Helicobacter pylori
- Cytotoxic Synergy between Indomethacin and Hydrochloric Acid in Gastric Mucosal Cells(Biochemistry/Molecular Biology)
- Antiproliferative Constituents from Umbelliferae Plants. V. A New Furanocoumarin and Falcarindiol Furanocoumarin Ethers from the Root of Angelica japonica
- Hydrophobic Scale : a Second Parameter to Elucidating Various Specific Ligand-Protein Interactions
- A New Application of Sequence Fourier Analysis to Specific Ligand-Protein Interactions
- Analysis of the Peptides (Prp106-126, MSI-78A, and Oxaldie 1) with the Same Biological Activity by Discrete Fourier Transform: Toward a Selection Rule in Ligand-Receptor Interaction
- 1P-090 ヒト由来2回膜貫通型タンパク質Ifitm5の構造研究 : NMR法を用いた立体構造解析のためのサンプル調製(膜蛋白質,第47回日本生物物理学会年会)
- Studies on Biological Activities of Melanin from Marine Animals. V. : Anti-inflammatory Activity of Low-Molecular-Weight Melanoprotein from Squid (Fr. SM II)(Biological)
- Ab lnitio CASSCF Study on Doublet and Quartet States of 1,3,5-Tris(methylene)benzene and 1,3,5-Benzenetriamine Trication
- Electron Spin Resonance of the Quartet State of 1,3,5-Tris(diphenylamino)benzene
- HOMOLOGY OF AN ACROSOME-REACTED SPERM-SPECIFIC ANTIGEN TO CD46
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G(IgG) by Chemical Modification and Active Subfragments. VII. Effect of Carboxamidemethylated Fc(CM-Fc) Fragment from Human Serum IgG on Lymphocytes and Macrophages(Pharmacological,Chemic
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G(IgG) by Chemical Modification and Active Subfragments. VI. Anti-allergic Activity of Carboxamidemethylated Fc(CM-Fc) Fragment from Human Serum IgG(Pharmacological,Chemical)
- Inhibitory Effect of Bis[2-(E-2-octenoylamino)ethyl] Disulfide and 2-(E-Octenoylamino)ethyl Carbamoylmethyl Sulfide on Various Inflammation Models(Biological,Chemical)
- Inhibitory Effect of Bis[2-(E-2-alkenoylamino)ethyl] Disulfides and 2-(E-Octenoylamino)ethyl Carbamoylmethyl Sulfides on Carrageenin-Induced Paw Edema in Rats(Biological,Chemical)
- Highly Selective Antibacterial Activity of Novel Alkyl Quinolone Alkaloids from a Chinese Herbal Medicine, Gosyuyu (Wu - Chu - Yu), against Helicobacter pylori In Vitro
- Structures and Electrical Properties of β- and θ-(BTM-TTP)_2SbF_6
- Synthesis and Biological Evaluation of Peptide Mimics Derived from First Extracellular Loop of CCR5 toward HIV-1
- Synthesis of Peptides Mimicking Chemokine Receptor CCR5 and Their Inhibitory Effects against HIV-1 Infection
- A Facile Synthesis of 2-Deoxy-2,3-didehydroneuraminic Acid Derivatives
- Two-Dimensional Band Structure of Organic Metals (BDT-TTP)_2X (X=SbF_6,AsF_6)Studied by Polarized Reflection Spectroscopy
- Theoretical Study of Lithium-Doped Polycyclic Aromatic Hydrocarbons
- Magnetic Properties of 1,3,5-Tris[bis(p-methoxyphenyl)amino]benzene Cation Radicals
- Reconsideration of the taxonomy of ellipsoidal species of Chlorella (Trebouxiophyceae, Chlorophyta), with establishment of Watanabea gen. nov.
- Antiproliferative Constituents from Umbelliferae Plants VI. New Ursane-Type Saikosaponin Analogs from the Fruits of Bupleunim rotundifolium
- Effects of Fluvastatin and Its Major Metabolites on Low-Density Lipoprotein Oxidation and Cholesterol Esterification in Macrophages
- Fluvastatin, an HMG-CoA Reductase Inhibitor, Protects LDL from Oxidative Modification in Hypercholesterolemic Rabbits
- In Vitro Inhibitory Effects of the Optical Isomers and Metabolites of Fluvastatin on Copper Ion-Induced LDL Oxidation
- An in Vitro Study of the Hydroxyl Radical Scavengin Property of Fluvastatin, and HMG-CoA Reductase Inhibitor
- An Alternative Base-Pairing of Catechol-Bearing Nucleosides by Borate Formation
- Inhibitory Effects of Fluvastatin and Its Metabolites on Hydrogen Peroxide-Induced Oxidative Destruction of Hemin and Low-Density Lipoprotein
- Michael-Type Addition of Illudin S, a Toxic Substance from Lampteromyces japonicus, with Cysteine and Cysteine-Containing Peptides in Vitro
- Green fluorescent protein as a marker in transgenic mice
- METABOLISM OF ILLUDIN-S, A TOXIC PRINCIPLE OF LAMPTEROMYCES JAPONICUS, BY RAT LIVER
- Novel Biological Activity of the Region (106-126) on Human Prion Sequence
- Biological Activities of 1,1,6-Trisubstituted Indanes : Beyond Magainin 2
- Antibacterial Activity of (±) 6-Benzyl-1-(3-carboxypropyl) indane; A Possible Way to Identify Leading Novel Anti-H. pylori Agents
- Antibacterial Activity of Two Alkylamines Integrated an Indane Scaffold : Mimicry of a Complementary Unit on Magainin 2
- Nanometer-Scale Lithography on the Oligosilane Langmuir-Blodgett Film
- On the Antibacterial Activity of Normal and Reversed Magainin 2 Analogs against Helicobacter pylori
- Deep Impurity Centers in CdS Single Crystals Studied by Spectral Analysis of Deep Level Transient Spectroscopy
- Synthesis and Properties of New Tetrathiapentalene Donors Composed of Vinylogous TTFs
- Synthesis of Fullerene-Porphyrin Complex
- Conducting Salts Composed of Selenium Analogues of TMET-TTP
- Conducting Salts Composed of Selenium Analogues of TMET-TTP
- Through-Bond and Through-Space Interactions of Organic Radicals Coupled by m-Phenylene
- Synthesis of Diazafluorene-functionalized TTF Donors
- STRESS TOLERANCE OF TOBACCO PLANTS WITH ENHANCED ACTIVITIES OF MANGANESE-CATALASE
- Synthesis of Reversed Magainin 2 Analogs Enhanced Antibacterial Activity
- Synthesis and Biological Activity of Four Kinds of Reversed Peptides
- Application of Sequence Fourier Analysis to a Specific Interaction in Arabidopsis thaliana
- Sequence Fourier Analysis of a Specific Protein–DNA (RNA) Interaction; an Intermolecular Frequency Symmetry
- Red Pigment Formation in Cultured Cells of Carthamus tinctorius L.
- COMPARISON OF ANTIOXIDATIVE CAPACITY AND STRESS TOLERANCE BETWEEN TWO TYPES OF TRANSGENIC TOBACCO PLANTS ENRICHED EITHER IN CHLOROPLASTS OR IN CYTOPLASM
- A Fourth Scale Sensitive to the Magnetic Field; Intermolecular Frequency Symmetry in a Specific Interaction between Protein and Low-Molecular Compound
- Construction of 1,3-Oxathiane Ring through Pummerer Reaction of γ, δ-Unsaturated Sulfinyl Compounds
- A newly isolated extracellular Mn-SOD from a moss Barbula unguiculata has a peptide sequence similarity with germin
- Differential Light Regulation of the rbcS Gene Expression in Two Cell Lines of the Liverwort Marchantia paleacea var.diptera
- Light-Dependent Expression of Protochlorophyllide Oxidoreductase Gene in the Liverwort, Marchantia paleacea var.diptera
- Fabrication of Shallow Silicon Nanoholes and Fixing Nanoparticles
- Preparation and Characterization of Gold-Titania Nanoparticles
- Convenient Transformation of Benzyl Alcohol into Its Corresponding Selenide Using the Selenolate Anion-Aluminum Chloride Combination System
- Occurrence and lithofacies of shungite : early Proterozoic carbon-rich rocks from Karelia, northwestern Russia
- Cleaning of Ge(110) Surfaces Using an Excimer Lamp
- Structures and Electrical Properties of (BTM-TS-TTP)_4PF_6
- Communication to the editor: Prediction of three-independent scales endowed on poliovirus proteinase 2A sequence
- Hollow Mesoporous Silica/Poly(l-lysine) Particles for Codelivery of Drug and Gene with Enzyme-Triggered Release Property
- Characterization of a cDNA Encoding CuZn-Superoxide Dismutase from the Liverwort Marchantia paleacea var.diptera
- CLONING AND CHARACTERIZATION OF cDNA FOR THE CuZn-SUPEROXIDE DISMUTASE FROM THE LIVERWORT CELL OF Marchantia paleacea var.diptera
- New Benzoxepin Glucoside from Transformed Root Cultures of Helianthus annuus L.
- Phenolics in Tissue Cultures of Scutellaria