Biological Activities of 1,1,6-Trisubstituted Indanes : Beyond Magainin 2
スポンサーリンク
概要
- 論文の詳細を見る
MSI-78 is a peptide analog of naturally occurring magainin 2 isolated from the skin of Xenopus laevis. The peptide is known to have one of the strongest antibacterial activities in magainin 2 analogs against methicillin-resistant Staphylococcus aureus (MRSA). To find novel compounds superior to MSI-78,we have further designed, synthesizing 1,1-di(4-aminobutyl)-6-benzylindane (PM4) and 1,1-dibenzyl-6-(4-aminobutyl) indane (PM5), and tested their inhibitory ability of the growth of S. aureus. In an in vitro assay, PM4 showed the same antibacterial activity against the bacterium as MSI-78,and non-hemolytic activity against human red blood cells (RBCs) at the MIC (minimum inhibitory concentration )value, in contrast to the latter. On the other hand, PM 5 showed stronger antibacterial activity than MSI-78,but being still accompanied with hemolysis at the MIC value. Otherwise, stronger decarboxylase activity for oxaloacetate was observed in PM5,rather than magainin 2 analogs or Oxaldie 1 as a control peptide, but not in PM4.
- 公益社団法人日本薬学会の論文
- 1999-01-15
著者
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Iwahori A
Hoshi Univ. Tokyo Jpn
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NUMAO Naganori
BioFrontier Institute Inc.
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KOBAYASHI Susumu
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Yamazaki Akiko
Department Of Earth Science School Of Education Waseda University
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Yamazaki Akiko
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kobayashi Susumu
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kobayashi Susumu
Department Of Pharmaceutical Sciences Tokyo University Of Science
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TAKAO Ken-ichi
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Numao N
Biofrontier Institute Inc.
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Itoh Etsuko
Sagami Chemical Research Center
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Itoh Sachiko
Sagami Chemical Research Center
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Numao Naganori
Sagami Chemical Research Center
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Kobayashi S
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat
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KAMINO Tomoyuki
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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SHIMOZONO Noriko
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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HIROTA Yukiko
Sagami Chemical Research Center
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IWAHORI Akiyo
Sagami Chemical Research Center
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KIDOKORO Shun-ichi
Sagami Chemical Research Center
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SASATSU Masanori
Showa College of Pharmaceutical Sciences
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KONDO Isamu
the Jikei University School of Medicine
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ITHO Sachiko
Sagami Chemical Research Center
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KATOH Tadashi
Sagami Chemical Research Center
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Hirota Y
Sagami Chemical Research Center
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Sasatsu M
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Kamino Tomoyuki
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Kidokoro S
Sagami Chemical Research Center
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Numao N
Biofrontier Inst. Inc.
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Shimozono Noriko
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Sasatsu Masanori
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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