Determination of the Absolute Structure of (+)-Akaterpin
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概要
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We describe the total synthesis and structural determination of (+)-akaterpin (1), an inhibitor of phosphatidylinositol-specific phospholipase C (PI-PLC). The key features of the synthetic strategy include the resolution of β,γ-unsaturated ketone (±)-2a with chiral sulfoximine 6. The absolute stereochemistry was determined by comparison of the specific optical rotation data of (+)-1 and (−)-1 with that of natural akaterpin.
著者
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Kobayashi Susumu
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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TAKAO Ken-ichi
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Nakazaki Atsuo
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Umezawa Kazuo
Department Of Applied Chemistry Faculty Of Science And Technology
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Suzuki Takahiro
Faculty Of Health Sciences Department Of Human Care Engineering Nihon Fukushi University
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Hosoi Hayato
Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI)
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Kawai Nobuyuki
Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI)
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Hagiwara Hideki
Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI)
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Takao Ken-ichi
Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI)
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