Induction of Apoptosis by Erbstatin in Mouse Leukemia L1210 Cells

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概要

• 論文の詳細を見る

• Erbstatin, a tyrosine kinase inhibitor, has antitumor activity on L1210 mouse leukemia. We tried to find the mechanism of this cytotoxic effect of erbstatin. Erbstatin increased trypan blue exclusion in cultured L1210 cells. The cytotoxic action of erbstatin was accompanied with shrinking of the cells and internucleosomal DNA fragmentation, characteristics of apoptosis. The DNA fragmentation was induced with other tyrosine kinase inhibitors as well, methyl 2,5-dihydroxycinnamate and herbimycin A. In addition, intracellular tyrosine phosphorylation was inhibited by erbstatin before cell death. Erbstatin-induced DNA fragmentation was prevented by zinc ions, but not by cycloheximide or 12-O-tetradecanoylphorbol 13-acetate (TPA). Thus, erbstatin induced apoptotic cell death in L1210 cells by inhibiting tyrosine kinase

• 社団法人日本農芸化学会の論文
• 1994-09-23

著者

• IMOTO Masaya

  Department of Applied Chemistry, Faculty of Science and Technology, Keio University

• Simizu Siro

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Imoto M

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Imoto Masaya

  Department Of Agricultural Chemistry Faculty Of Agriculture Yamaguchi University

• Umezawa K

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Umezawa Kazuo

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Momose Isao

  Numazu Bio-medical Research Institute Microbial Chemistry Research Center

• Umezawa Kazuo

  Department Of Applied Chemistry Faculty Of Science And Technology

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