A New Proteasome Inhibitor, TP-110, Induces Apoptosis in Human Prostate Cancer PC-3 Cells
スポンサーリンク
概要
- 論文の詳細を見る
Proteasome inhibitors are useful in the treatment of cancer. Recently, we found a new proteasome inhibitor, TP-110, derived from tyropeptin A produced by Kitasatospora sp. Here we report that TP-110 induces apoptosis in human prostate cancer PC-3 cells. TP-110 showed strong cytotoxicity to PC-3 cells (IC50=0.05 μM). It increased the number of cells in the G2-M phase and increased the accumulated amounts of the p21 and p27 proteins, which are negative regulators of cell cycle progression. Furthermore, it induced apoptosis along with chromatin condensation and DNA fragmentation in PC-3 cells, and TP-110-induced apoptosis appeared to be associated with caspase activation. Additionally, TP-110 inhibited not only the degradation of IκB and the nuclear translocation of nuclear factor-κB (NF-κB), but also the DNA binding activity of NF-κB. These results indicate that TP-110 shows a strong growth inhibition and apoptosis in PC-3 cells.
- 社団法人 日本農芸化学会の論文
- 2007-04-23
著者
-
ISHIZUKA Masaaki
Institute for Chemotherapy
-
IKEDA Daishiro
Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center
-
MOMOSE Isao
Institute of Microbial Chemistry
-
Imoto M
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
-
Kawada Manabu
Numazu Bio-medical Research Institute Microbial Chemistry Research Foundation
-
Kawada Manabu
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
-
Kawada Manabu
School Of Materials Science Japan Advanced Institute Of Science And Technology
-
Ikeda D
Numazu Bio-medical Research Institute Microbial Chemistry Research Foundation
-
Ikeda Daishiro
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
-
Iijima Masatomi
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
-
MOMOSE Isao
Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center
-
Momose Isao
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
-
Kawada Manabu
微生物化学研究会微生物化学研究センター沼津創薬医科学研究所 創薬基盤研究ユニット
関連論文
- Synthesis and Activities of Bactobolin Derivatives Based on the Alteration of the Functionality at C-3 Position
- Absolute Configuration of Migrastatin, a Novel 14-Membered Ring Macrolide
- Migrastatin, a Novel 14-Membered Ring Macrolide, Inhibits Anchorage-independent Growth of Human Small Cell Lung Carcinoma Ms-1 Cells
- Synthesis and Biological Evaluation of Cytogenin Derivatives
- Migrastatin, a Novel 14-Membered Lactone from Streptomyces sp. MK929-43F1
- Inhibition of Angiogenesis by a New Isocoumarin, NM-3
- Structure of Ericamycin Having a 2-Azhexaphene Ring System
- Selective Deoxygenation and O-Methylation of Benanomicin A:Synthesis of 9-Deoxy-, 9-O-Methyl- and 14-O-Methylbenanomicin A
- A Synthetic Approach to Benanomicin A 2. Synthesis of the Substituted 5,6-Dihydrobenzo[a]naphthacenequinone
- A Synthetic Approach to Benanomicin A 1. Synthesis of 5,6-Dihydrobenzo[a]naphthacenequinone
- Synthesis an Optically Active α-Tetralone : A Key Intermediate to Natural Benanomicinone
- A Synthetic Approach to Benanomicin A : Synthesis of the Substitute 5, 6-Dihydrobenzo[a]naphthacenequinone
- ICM0301s, New Angiogenesis Inhibitors from Aspergillus sp. F-1491 : II. Physico-chemical Properties and Structure Elucidation
- Anthracyclines, Small-Molecule Inhibitors of Hypoxia-Inducible Factor-1 Alpha Activation(Molecular and Cell Biology)
- ICM0201, a New Inhibitor of Osteoclastogenesis from Cunninghamella sp. F-1490 II. Structure Determination and Synthesis
- ICM0201, a New Inhibitor of Osteoclastogenesis from Cunninghamella sp. F-1490 I. Taxonomy, Fermentation, Isolation and Biological Activities
- Inhibition of Proteasome Activity by Tyropeptin A in PC12 Cells(Biochemistry & Molecular Biology)
- Inhibitory Activity of Dome Formation in LLC-PK_1 Cells Is a Selective Index of Aminoglycoside Nephrotoxicity
- Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2 : II. Structure Determination and Synthesis
- Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2 : I. Taxonomy, Isolation, Physico-chemical Properties and Biological Activities
- Isolation and Structural Determination of Phepropeptins A, B, C, and D, New Proteasome Inhibitors, Produced by Streptomyces sp.
- Inhibition of Ribonucleotide Reductase Activity by IC202C
- Biosynthesis of IC202C, a New Siderophore with Immunosuppressive Activity
- Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1 : Taxonomy, Fermentation, Isolation and Biological Activities
- MK800-62F1, a New Inhibitor of Apoptotic Cell Death, from Streptomyces diastatochromogenes MK800-62F1 : II. Structure Elucidation
- MK800-62F1, a New Inhibitor of Apoptotic Cell Death, from Streptomyces diastatochromogenes MK800-62F1 : I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity
- Diperamycin, a New Antimicrobial Antibiotic Produced by Streptomyces griseoaurantiacus MK393-AF2 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
- Effect of a Novel Antibiotic, Heliquinomycin, on DNA Helicase and Cell Growth
- Cremimycin, a Novel 19-Membered Macrocyclic Lactam Antibiotic, from Streptomyces sp.
- Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis II. Effect on Type II Collagen-induced Arthritis in Mice
- Heliquinomycin, a New Inhibitor of DNA Helicase, Produced by Streptomyces sp. MJ929-SF2 II. Structure Determination of Heliquinomycin
- Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone
- New Strobilurins O and P from a Mushroom
- Melleolides K, L and M, New Melleolides from Armillariella mellea
- Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. MK73-NF4 II. Structure Determination
- Decatromicins A and B, New Antibiotics Produced by Actinomadura sp. MK73-NF4 I. Taxonomy, Isolation, Physico-chemical Properties and Biological Activities
- Nothramicin, a New Anthracycline Antibiotic from Nocardia sp. MJ896-43F17
- Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1 II. Structure Determination
- Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1 I. Taxonomy, Production, Isolation, Physico-chemical Properties and Biological Activities
- Potentiation of Paclitaxel Cytotoxicity by Inostamycin in Human Small Cell Lung Carcinoma, Ms-1 Cells
- Caspase-3 Activation Is Not Responsible for Vinblastine-induced Bcl-2 Phosphorylation and G2/M Arrest in Human Small Cell Lung Carcinoma Ms-1 Cells
- Inhibition of Cyclin D1 Expression and Induction of Apoptosis by Inostamycin in Small Cell Lung Carcinoma Cells
- Effect of Cytogenin, a Novel Immunomodulator, on Streptozotocin-induced Diabetes in Mice
- Catalytic Electrochemistry of Poly (ethylene glycol)-Modified Galactose Oxidase in Organic Solvents
- ICM0301s, New Angiogenesis Inhibitors from Aspergillus sp. F-1491 : I. Taxonomy, Fermentation, Isolation and Biological Activities
- Tripropeptins, Novel Antimicrobial Agents Produced by Lysobacter sp. II. Structure Elucidation
- Inhibition of CTP : Phosphocholine Cytidyltransferase Activity by 15-Deoxyspergualin
- Absolute Configuration of Kigamicins A, C and D
- Synthesis of Gerfelin and Related Analogous Compounds
- Synthesis and Activity of Tyropeptin A Derivatives as Potent and Selective Inhibitors of Mammalian 20S Proteasome
- Rakicidin A : A Hypoxia-Selective Cytotoxin(Molecular and Cell Biology)
- The Long-lasting Antiproliferative Effect of 15-Deoxyspergualin through its Spermidine Moiety
- Inhibitory Effect of Cytostatin on Spontaneous Lung Metastases of B16-BL6 Melanoma Cells
- Modulation of Macrophage Activity in Tumor Bearing Mice by Cytogenin
- Antitumor Activity of Cytogenin
- Highly tumorigenic human androgen receptor-positive prostate cancer cells overexpress angiogenin
- Differential Induction of Apoptosis in B16 Melanoma and EL-4 Lymphoma Cells by Cytostatin and Bactobolin
- IC202A, a New Siderophored with Immunosuppressive Activity Produced by Streptoalloteichus sp. 1454-19 II. Physico-chemical Properties and Structure Elucidation
- Screening for Apoptosis Inducers in Microbial Products and Induction of Apoptosis by Cytostatin
- PP2A Inhibitors, Harzianic Acid and Related Compounds Produced by Fungus Strain F-1531
- Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis
- Augmentation of Cellular Immunity by Kigamicin D
- Antitumor Effect of Kigamicin D on Mouse Tumor Models
- IC202A, a New Siderophore with Immunosuppressive Activity Produced by Streptoalloteichus sp. 1454-19 I. Taxonomy, Fermentation, Isolation and Biological Activity
- Action of Cytogenin on Lymphoid Cells and Their Cytokine Production
- Phthoxazolin A inhibits prostate cancer growth by modulating tumor-stromal cell interactions
- A New Terrein Glucoside, a Novel Inhibitor of Angiogenin Secretion in Tumor Angiogenesis
- A New Proteasome Inhibitor, TP-110, Induces Apoptosis in Human Prostate Cancer PC-3 Cells
- Inhibitory Activity of the Hypoxia-inducible Factor-1 Pathway by Tartrolone C
- Prevention of Neomycin-induced Nephrotoxic Event in Pig Proximal Tubular Epithelial Cell Line by Apolipoprotein E3
- Enhancement of Antiproliferative Effects of Interleukin-1β and Tumor Necrosis Factor-α on Human Prostate Cancer LNCaP Cells by Coculture with Normal Fibroblasts through Secreted Interkeukin-6
- Increased ABCB1 Expression in TP-110-Resistant RPMI-8226 Cells
- IC202B and C, New Siderophores with Immunosuppressive Activity Produced by Streptoalloteichus sp. 1454-19
- Improvement of Efficacy of Antitumor Agents by Conagenin
- Induction of Apoptosis by Erbstatin in Mouse Leukemia L1210 Cells
- New atpenins, NBRI23477 A and B, inhibit the growth of human prostate cancer cells
- Ceramidastin, a novel bacterial ceramidase inhibitor, produced by Penicillium sp. Mer-f17067
- NBRI17671, a new antitumor compound, produced by Acremonium sp. CR 17671
- NBRI16716A, a new antitumor compound against human prostate cancer cells, produced by Perisporiopsis melioloides Mer-f16716
- Citric acid inhibits a bacterial ceramidase and alleviates atopic dermatitis in an animal model
- Studies of the effect of spermidine in enhancing cellular immunity.