Rakicidin A : A Hypoxia-Selective Cytotoxin(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
Hypoxia is a common feature of many solid tumors and contributes to their progression. Hypoxic cells in the tumor are not only involved in therapeutic resistance to chemotherapy and radiotherapy but are also relevant to tumor angiogenesis. To identify novel hypoxia-selective cytotoxins, we screened 20000 cultured broths of microorganisms and found that rakicidin A showed significant hypoxia-selective cytotoxicity. Rakicidin A was approximately 17.5-fold more cytotoxic under hypoxic than under normoxic conditions. CoCl_2 and antioxidants had no effect on the rakicidin A cytotoxicity under normoxic conditions and rakicidin A did not show the inhibitory effects on HIF-1 transcriptional activity under hypoxic conditions. Thus, although the action mechanism of the hypoxia-selective cytotoxicity of rakicidin A was unknown, our screening study suggested that rakicidin A acts as an antitumor agent for selective therapy against solid tumors.
- 公益社団法人日本薬学会の論文
- 2007-02-01
著者
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Yamazaki Yohko
微生物化学研究会微生物化学研究センター沼津創薬医科学研究所
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YAMAZAKI Yohko
Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center
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KUNIMOTO Setsuko
Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center
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IKEDA Daishiro
Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center
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Yamazaki Yoko
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
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Yamazaki Yohko
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
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Ikeda Daishiro
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
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Kunimoto S
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
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Kunimoto Setsuko
Numazu Bio-medical Research Institute Microbial Chemistry Research Center
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山嵜 行由
School Of Pharmaceutical Sciences University Of Shizuoka
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