Lipase-Catalyzed Enantioselective Hydrolysis of Bis(acyloxymethyl) 1,4-Dihydro-3,5-pyridinedicarboxylates Leading to Optically Active Medicines

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概要

• 論文の詳細を見る

• Chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates and 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate have been obtained in 80-99%ee by lipase-catalyzed hydrolysis of bis(acyloxymethyl) 1,4-dihydro-3,5-pyridinedicarboxylate in an H_2O/organic solvent system. These chiral dihydropyridines were readily converted into chiral drugs, such as nicardipine, felodipine and PCA 4248.

• 公益社団法人日本薬学会の論文
• 1997-05-15

著者

• 阿知波 一雄

  静岡県立大学薬学部

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 阿知波 一雄

  静岡県大薬

• 阿知波 一雄

  東大・薬

• Maruyama K

  帝京大学 薬 薬剤

• Yamazaki Yohko

  微生物化学研究会微生物化学研究センター沼津創薬医科学研究所

• ACHIWA Kazuo

  School of Pharmaceutical Sciences, University of Shizuoka

• Yamazaki Yoko

  Numazu Bio-medical Research Institute Microbial Chemistry Research Center

• Sasaki I

  Yamanouchi Pharmaceutical Co. Ltd. Shizuoka Jpn

• Achiwa Kazuo

  School Of Pharmaceutical Sciences University Of Shizuoka

• Achiwa Kazuo

  School Of Pharmaceutical Sciences(laboratory Of Medicinal Chemistry)

• EBIIKE Hirosato

  School of Pharmaceutical Sciences, University of Shizuoka

• MARUYAMA Kaori

  School of Pharmaceutical Sciences, University of Shizuoka

• YAMAZAKI Yukiyoshi

  School of Pharmaceutical Sciences, University of Shizuoka

• HIROSE Yoshihiko

  Central Research Laboratory, Amano Pharmaceutical Co., Ltd.,

• KARIYA Kinya

  Central Research Laboratory, Amano Pharmaceutical Co., Ltd.,

• SASAKI Ikuharu

  Central Research Laboratory, Amano Pharmaceutical Co., Ltd.,

• KURONO Yoshiaki

  Central Research Laboratory, Amano Pharmaceutical Co., Ltd.,

• TERAO Yoshiyasu

  Division of Environmental Health Sciences, Graduate School of University of Shizuoka

• Kariya Kinya

  Central Research Laboratory Amano Pharmaceutical Co. Ltd.

• Ebiike H

  School Of Pharmaceutical Sciences University Of Shizuoka

• Ebiike Hirosato

  School Of Pharmaceutical Sciences University Of Shizuoka

• 桐山 美由紀

  Meiji Pharmaceutical Univ. Tokyo Jpn

• Terao Yoshiyasu

  Division Of Environmental Health Sciences Graduate School Of University Of Shizuoka

• Kurono Y

  Central Research Laboratory Amano Pharmaceutical Co. Ltd.

• Maruyama K

  Kyoto Pharmaceutical University

• Hirose Yoshihiko

  Central Research Laboratory Amano Pharmaceutical Co. Ltd.

• 山嵜 行由

  School Of Pharmaceutical Sciences University Of Shizuoka

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