不斉点から離れた位置に官能基を持つ化合物における酵素触媒不斉反応
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The synthetic method of optically active compound by using lipase-catalysis in organic solvent has been generally accepted recently. Because lipases possess especially broad substrate specificity and are commercially available. However, efficient substrates of lipase-catalyzed asymmetric reactions were limited to be the compounds whose stereogenic carbon atoms were in the neighborhood of the reaction site.<BR>This review describes our investigation on substrates of which stereogenic carbon atoms are remote from the reacting site, leading to lipase-catalyzed asymmetric synthesis of optically active synthetic drugs.
- 社団法人 有機合成化学協会の論文
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