Synthesis of Optically Active Nucleoside Analogs Containing 2,3-Dideoxyapiose in the Presence of a Catalytic Amount of Trimethylsilyl Iodide

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概要

• 論文の詳細を見る

• Optically pure (R)-4,4-diethoxy-2-(hydroxymethyl)butyl acetate (1) was synthesized enantioselectively by lipase-catalyzed transesterification from 4,4-diethoxy-2-(hydroxymethyl)butanol. Coupling of silylated nucleobases and 2-O-acetyl-5-O-pivaloyl-(3S)-2,3-dideoxyapiose (2) prepared from 1 was found to proceed smoothly in the presence of a catalytic amount of trimethylsilyl iodide under mild conditions to afford optically active nucleoside analogs.

• 社団法人日本薬学会の論文
• 1993-11-15

著者

• 阿知波 一雄

  静岡県立大学薬学部

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 阿知波 一雄

  静岡県大薬

• 塩沢 竜志

  静岡県立大学

• 塩沢 竜志

  Graduate School of Nutritional & Environmental Sciences, University of Shizuoka

• 寺尾 良保

  Graduate School of Nutritional & Environmental Sciences, University of Shizuoka

• 大沢 桂子

  Graduate School of Nutritional and Environmental Sciences

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