Synthesis of Tn, Sialyl Tn and HIV-1-Derived Peptide Antigen Conjugates Having a Lipid A Analog as an Immunoadjuvant for Synthetic VAaccines

スポンサーリンク

概要

• 論文の詳細を見る

• Conjugates (3-5) of Tn, sialyl Tn and HIV-1-derived peptide antigen with a N-tetradecanoyl L-serine-β-alanine-containing D-glucosamine derivative, structurally related to lipid A, as an immunoadjuvant for the development of totally synthetic vaccines against cancers or HIV were synthesized. The mitogenic activity of compounds 3,4 and 5 was stronger than that of lipid A analogs (1,2).

• 公益社団法人日本薬学会の論文
• 1998-11-15

著者

• 阿知波 一雄

  静岡県立大学薬学部

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 阿知波 一雄

  静岡県大薬

• 阿知波 一雄

  東大・薬

• 池田 潔

  School Of Pharmaceutical Sciences University Of Shizuoka

• 池田 潔

  Tanabe Seiyaku Co. Ltd. Saitama Jpn

• ACHIWA Kazuo

  School of Pharmaceutical Sciences, University of Shizuoka

• IKEDA Kiyoshi

  School of Pharmaceutical Sciences, University of Shizuoka

• MIYAJIMA Keisuke

  School of Pharmaceutical Sciences, University of Shizuoka

• NEKADO Takahiro

  School of Pharmaceutical Sciences, University of Shizuoka

• Achiwa Kazuo

  School Of Pharmaceutical Sciences University Of Shizuoka

• Achiwa Kazuo

  School Of Pharmaceutical Sciences(laboratory Of Medicinal Chemistry)

• Ikeda Kiyoshi

  Department Of Biochemistry Osaka University Of Pharmaceutical Sciences

• 池田 かおり

  Developmental Research Laboratories Shionogi & Co. Ltd.

• Ikeda Kaori

  Developmental Research Laboratories Shionogi & Co. Ltd.

• Nekado T

  School Of Pharmaceutical Sciences University Of Shizuoka

• Miyajima K

  Department Of Otolaryngology Tokyo Women's Medical University Daini Hospital

• Ikeda Kiyoshi

  School Of Information Science Japan Advanced Institute Of Science And

関連論文

• 98 蜂過敏症におけるPAFアセチルハイドラーゼ(PAF-AH)活性の検討
• Prostanoids and Related Compounds. IV. Total Synthesis of Clavulones
• PYRROLIDINE DERIVATIVES AS INHIBITORS OF PLATELET AGGREGATION INDUCED BY PLATELET ACTIVATING FACTOR
• Convenient Syntheses of Optically Active β-Lactams by Enzymatic Resolution
• Synthesis of Optically Active Nucleoside Analogs Containing 2,3-Dideoxyapiose in the Presence of a Catalytic Amount of Trimethylsilyl Iodide
• LIPASE-CATALYZED ENANTIOSYNTHESIS OF (R)- AND (S)-2-[BENZYL(PHENYL)AMINO]ETHYL 5-(5,5-DIMETHYL-2-OXO-1,3,2-DIOXAPHOSPHORINAN-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3-PYRIDINECARBOXYLATE (NZ 105)
• DETERMINATION OF THE ABSOLUTE CONFIGURATION OF BIOLOGICALLY ACTIVE (S)-(-)-NB 818 AND ITS STRUCTURAL CORRELATION WITH THE STEREOSELECTIVITY OF THE CHANNEL BLOCKING ACTION
• LIPASE-CATALYZED ENANTIOSELECTIVE HYDROLYSIS OF 4-ALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES : SYNTHESIS OF (+)- AND (-)-METHYL 2-(PHENYLTHIO)ETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE (PCA 4248)
• SYNTHESIS AND INHIBITORY ACTIVITY OF ISOINDOLINONE DERIVATIVES ON THROMBOXANE A_2 ANALOG (U-46619)-INDUCED VASOCONTRACTION
• キラル医薬品の研究開発をどう進めるか
• Development of New 6-Membered Chelating Chiral Bisphosphine Ligands for Rhodium-Catalyzed Asymmetric Hydrogenation
• THE ORIGIN OF THE ENANTIOSELECTION IN THE RUTHENIUM(II)-CATALYZED ASYMMETRIC HYDROGENATION OF α, β-UNSATURATED CARBOXYLIC ACID
• ^P-Nuclear Magnetic Resonance Studies on Various N-Substituted Pyrrolidinebisphosphine-Rhodium Complexes to Clarify the N-Substituent Effect on Catalytic Asymmetric Hydrogenation
• Efficient Preparation of Optically Active (S)-(-)-3-Methyl-γ-butyrolactone by Catalytic Asymmetric Hydrogenation Using Chiral N-Substituted Pyrrolidinebisphosphine Rhodium Complexes
• 2.触媒的不斉水素化反応(触媒的不斉合成)
• EFFECIENT ASYMMETRIC HYDROGENATION OF (Z__-)-2-ACETAMIDOCINNAMIC ACID CATALYZED BY THE RHODIUM COMPLEX OF MODIFIED N__--BENZYL-(3R__-, 4R__-)-3,4-BIS(DIPHENYLPHOSPHINO)PYRROLIDINE (DEGPHOS)
• A Convenient Synthesis of N-Benzyloxy-β-lactams via N-Benzyloxyimines
• Mitogenic Activity and the Induction of Tumor Necrosis Factor by Lipopeptide Analogs of the N-Terminal Part of Lipoprotein in the Outer Membrane of Escherichia coli
• Low Mitogenic Activity of Synthetic Lipid A Analog, 2,3-Acyloxyacylgalactosamine-4-phosphate, in Cultured Murine Splenocytes
• SYNTHESIS OF THE 2', 3'-DIDEOXYNUCLEOSIDE DERIVATIVES OF THE SPECIFIC BINDING PEPTIDE PART OF CD4
• Effect of Hydrophobically-Modified Hydroxypropyl Methylcellulose on the Crystallization from Supersaturated Solutions of Indomethacin
• Chromogenic Assay for the Activity of Sphingomyelinase from Bacillus cereus and Its Application to the Enzymatic Hydrolysis of Lysophospholipids(Analytical Biochemistry)
• His151 and His296 Are the Acid-Base Catalytic Residues of Bacillus cereus Sphingomyelinase in Sphingomyelin Hydrolysis
• Roles of Asp126 and Asp156 in the Enzyme Function of Sphingomyelinase from Bacillus cereus^1
• Mg^ Binding and Catalytic Function of Sphingomyelinase from Bacillus cereus
• Efficient Lipase-Catalyzed Synthesis of Chiral Glycerol Derivatives
• FACILE PROCESS FOR ENZYMIC RESOLUTION OF RACEMIC ALCOHOLS
• Disaccharides as Endomannosidase Inhibitors : Syntheses of α-Homomannojirimycin and β-Homomannojirimycin Linked to D-Glucose and D-Mannose
• Lipid A and Related Compounds. XXIX. Synthesis of Biologically Active N-Acylated L-Asparagine-Containing D-Glucosamine Derivatives Structurally Related to Lipid A
• 25 触媒的不斉水素化を鍵反応とする光学活性リグナン類の合成(口頭発表の部)
• Isolation and Amino Acid Sequence of a Phospholipase A_2 Inhibitor from the Blood Plasma of the sea Krait, Laticauda semifasciata
• Lipid A and Related Compounds. XV. Efficient Synthesis of Novel Analogs of Glucosamine-4-phosphate, the Nonreducing Sugar Moiety of Lipid A(Medicinal Chemistry,Chemical)
• Lipid A and Related Compounds. XIV. A New Synthesis of Lipid Y, the Reducing Sugar Moiety of Salmonella- and Proteus-Type Lipid A(Organic,Chemical)
• Lipid A and Related Compounds. XI. New, Efficient Synthesis of Lipid X(Organic,Chemical)
• SYNTHESIS OF CHIRAL 3-SUBSTITUTED γ-LACTONES AND 9-FURANOSYLADENINE FROM (R)-2-(2,2-DIETHOXYETHYL)-1,3-PROPANEDIOL MONOACETATE PREPARED BY LIPASE-CATALYZED REACTION
• SYNTHESIS OF ATROPISOMERIC BIPHENYLBISPHOSPHINE, 6,6'-BIS(DICYCLO-HEXYLPHOSPHINO)-3,3'-DIMETHOXY-2,2', 4,4'-TETRAMETHYL-1,1'-BIPHENYL AND ITS USE IN RHODIUM(I)-CATALYZED ASYMMETRIC HYDROGENATION
• SYNTHESIS OF AXIALLY DISSYMMETRIC BIPHENYLBISPHOSPHINE LIGANDS, BIMOPS AND ASYMMETRIC HYDROGENATIONS OF β-KETO ESTER AND α, β-UNSATURATED CARBOXYLIC ACID CATALYZED BY THEIR RUTHENIUM (II) COMPLEXES
• Neuraminic Acid and Related Compounds. V. Syntheses of Biologically Active Sialosyl-Glycerol Derivatives and Galactosyl-Glycerol Derivative
• SYNTHESES OF BIOLOGICALLY ACTIVE SIALOSYLGLYCEROL DERIVATIVES
• Neuraminic Acid and Related Compounds. I. : Syntheses of Biologically Active 4', 7', 8', 9'-Tetra-O-acetyl-sialyl- and Sialyl-(α2-6)-D-glucosamine-4-phosphate Analogues of Lipid A
• Lipid A and Related Compounds. XXXVII. Determination of Favorable Binding Linkages of Lipid A Analog to Antigen Moiety for Synthetic Vaccines
• Synthesis of Cancer Peptide Antigen-Lipid A Analog Conjugates for Synthetic Vaccines
• Synthesis of Tn, Sialyl Tn and HIV-1-Derived Peptide Antigen Conjugates Having a Lipid A Analog as an Immunoadjuvant for Synthetic VAaccines
• 細菌内毒素リピドA類を免疫アジュバント部位とする癌,エイズ合成ワクチンヘの基礎研究
• SYNTHESIS OF TN AND SIALYL TN ANTIGEN-LIPID A ANALOG CONJUGATES FOR SYNTHETIC VACCINES
• Lipid A and Related Compounds. XXXIII.Synthesis and Structure-Activity Relationships of N-Acylated L-Serine or L-Threonine-Containing D-Glucosamine Derivatives as Mimics of Lipid A Disaccharide
• Lipid A and Related Compounds. XXXI.Synthesis of Biologically Active N-Acylated L-Serine-Containing D-Glucosamine 4-Phosphate Derivatives of Lipid A
• Lipid A and Related Compounds. XXX. Synthesis of Biologically Active N, N'-Diacyl Chitobiose Derivatives Structurally Related to Lipid A
• Synthesis of Ganglioside G_ and G_ Analogs Having Mimics of Ceramide Moieties and Their Binding Activities with Influenza Virus A
• Synthesis of Sulfated Cerebroside Analogs Having Mimicks of Ceramide and Their Anti-human Immunodeficiency Virus Type 1 Activities
• SYNTHESIS OF BIOLOGICALLY ACTIVE N-ACYLATED L-SERINE-CONTAINING D-GLUCOSAMINE-4-PHOSPHATE DERIVATIVES OF LIPID
• Lipid A and Related Compounds. XXVII. An Efficient Synthesis of D-Galactosamine-4-phosphate Analogs of Lipid A via a Novel Key Intermediate
• Lipid A and Related Compounds. XXVI. Syntheses of Biologically Active Penta-O-acetyl-N-glycoloylneuraminyl- and Penta-O-acetyl-3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic Acid-(α2→6)-D-glucosamine-4-phosphate Analogs of Lipid A
• SYNTHESIS OF THE SEQUENCE OF HEPT-(α1→5)KDO-(α2→6)-D-GLUCOSAMINE-4-PHOSPHATE OF LIPOPOLYSACCHARIDE
• Lipid A and Related Compounds. XXIV. Efficient Synthesis of Several Lipid as via Common Disaccharide Intermediates
• SYNTHESIS OF BIOLOGICALLY ACTIVE DERIVATIVES OF D-GLUCOSAMINE-4-PHOSPHATE AND 1-THYMINYL-D-GLUCOSAMINE-4,6-DISULFATE
• A NEW SYNTHESIS OF α-GLYCOSIDICALLY-LINKED DISACCHARIDES USING 2α-CHLORO-3β-PHENYLTHIO KDO DERIVATIVES
• Synthesis and Biological Evaluation of Peptide Mimics Derived from First Extracellular Loop of CCR5 toward HIV-1
• Synthesis of Peptides Mimicking Chemokine Receptor CCR5 and Their Inhibitory Effects against HIV-1 Infection
• Synthesis of 2-Thio-platlet Activating Factor and Related Compounds
• Efficient Synthesis of Optically Active cis-endo-2,3-Dihydroxymethyl-5-norbornene Monoacetate by Lipase-Catalyzed Transesterification
• Lipase-Catalyzed Enantioselective Synthesis of Optically Active Mephobarbital, Hexobarbital and Febarbamate
• Steric and Electronic Effects of Substrates and Rhodium Chiral Catalysts in Asymmetric Cyclopropanation
• 光学活性医薬品の触媒的不斉合成研究
• Synthesis of (β-N-Sulfonylaminoalkyl)phosphines and Their Use in Palladium-Mediated Asymmetric Synthesis
• Efficient Asymmetric Hydrogenation of β- and γ-Amino Ketone Derivatives Leading to Practical Synthesis of Fluoxetine and Eprozinol
• Efficient Asymmetric Hydrogenation of α-Amino Ketone Derivatives. A Highly Enantioselective Synthesis of Phenylephrine, Levamisole, Carnitine and Propranolol
• EFFICIENT ASYMMETRIC HYDROGENATION OF IMINES CATALYZED BY A NEUTRAL IRIDIUM(I) COMPLEX OF (4R, 5R)-MOD-DIOP
• SYNTHESIS OF IMMUNOADJUVANT CONJUGATES WITH HIV-DERIVED PEPTIDE INDUCING PEPTIDE-SPECIFIC ANTIBODY
• Preparations of Chiral Pyrrolidinebisphosphines Bearing Two Different Types of Phosphino Groups and Their Use in Efficient Catalytic Asymmetric Hydrogenation
• Prostanoids and Related Compounds. VI. Synthesis of Isoindolinone Derivatives Possessing Inhibitory Activity for Thromboxane A_2 Analog (U-46619)-Induced Vasoconstriction
• Synthesis and Mitogenic Activity of Chiral Lipopeptide WS1279 and Its Derivatives
• STRUCTURE-ACTIVITY RELATIONSHIP OF LIPOPEPTIDE FROM OUTER MEMBRANE OF ESCHERICHIA COLI AND SYNTHESIS OF HIGHLY IMMUNOPOTENTING LIPOPEPTIDE DERIVATIVES WITH AN ACHIRAL LIPO-PART
• Synthesis of Optically Active Lipopeptide Analogs from the Outer Membrane of Escherichia coli
• SYNTHESIS OF BIOLOGICALLY ACTIVE PENTAPEPTIDE ANALOGS OF THE N-TERMALNAL PART OF LIPOPROTEIN FROM THE OUTER MEMBRANE OF ESCHERICHIA COLI
• SYNTHESIS OF BIOLOGICALLY ACTIVE GALACTOSYL AND GLUCOSYL-GLYCEROL DERIVATIVES
• 108(P40) 植物培養細胞を用いるポドフィロトキシン誘導体等の合成研究(ポスター発表の部)
• Synthesis of Optically Active α-Phenylpyridylmethanols with Cell Cultures of Nicotiana tabacum
• P-44 トコフェロール基本骨格の光学活性クロマンエタノールの酵素触媒合成(ポスター発表の部)
• Synthesis of Optically Active α-Phenylpyridylmethanols with Baker's Yeast
• 60 天然型α-トコフェロールの酵素触媒による合成(ポスター発表の部)
• Prostanoids and Related Compounds. V. Synthesis of 6-Aza-5-oxo-2,3,4-trinor-1,5-inter-m-phenylene Prostacyclin Derivatives
• Synthesis of Optically Active α-(p-Chlorophenyl)pyridylmethanols with Plant Cell Cultures
• Effect of Inhibitor or Immobilization on Reduction of Benzoylpyridines by Baker's Yeast
• Asymmetric Synthesis of (R)-Nilvadipine and (S)-NB 818 via Regioselective Bromination of Chiral 1,4-Dihydropyridines as a Key Step and Enzymatic Resolution of Racemic 2-Hydroxymethyl-1,4-dihydropyridine Derivatives
• Lipase-Catalyzed Enantioselective Hydrolysis of Bis(acyloxymethyl) 1,4-Dihydro-3,5-pyridinedicarboxylates Leading to Optically Active Medicines
• Synthesis of Efficient Chiral Bisphosphine Ligands, Modified DIOPs, (4R, 5R)-4-(Diaryl- or dialkylphosphino)methyl-5-(diarylphosphino)methyl-2,2-dimethyl-1,3-dioxolanes, and Their Use in Rhodium(I)-Catalyzed Asymmetric Hydrogenations
• EFFECTS OF THE DIARYLPHOSPHINO GROUPS OF MODIFIED DIOPS ON THE ENANTIOSELECTIVITY AND THE CATALYTIC ACTIVITY OF THEIR PHODIUM(I) COMPLEXES IN THE CATALYTIC ASYMMETRIC HYDROGENATIONS OF ENAMIDES
• EFFICIENT SYNTHESIS OF NATURAL (+)-COLLINUSIN USING CATALYTIC ASYMMETRIC HYDROGENATION WITH A CHIRAL BISPHOSPHINE-RHODIUM(I) COMPLEX
• Antibody-Producing Effects in Mice by Synthetic Immunoactive Lipopeptides with the Conjugated Amino Acid Sequence of gp120 in Human Immunodeficiency Virus
• 超効率不斉水素化触媒の開発と実用的不斉合成への応用
• DESIGN OF METHOXY-SUBSTITUTED BPPM ANALOGUES AND THEIR APPLICATION TO THE ASYMMETRIC SYNTHESIS OF N__-ACETYLPHENYLALANINE
• Lipid A and Related Compounds. XVII. : Synthesis of 3- Deoxy-D-manno-2-octulosonic Acid (KDO)-(α2→6)-D-Glucosamine-4-phosphates, Analogs of the Biologically Active Moiety of Lipopolysaccharide from Escherichia coli Re Mutant
• Lipid A and Related Compounds. XVI. Synthesis of Biologically Active Tetraacetyl-3-deoxy-D-manno-2-octulosonic Acid (KDO)-(α2→6)-D-Glucosamine-4-phosphates, Novel Analogs of the Nonreducing Sugar Moiety of Lipid A(Medicinal Chemistry,Chemical)
• Synthesis of N-Acetylglucosaminyl- and N-Acetylgalactosaminylceramides as Cerebroside Analogs and Their Anti-human Immunodeficiency Virus Type 1 Activities
• NEW SYNTHESIS OF 2-THIO-PAF AND RELATED COMPOUNDS AS SUBSTRATES OF PAF ACETYLHYDROLASE AND PHOSPHOLIPASE A_2
• 有機溶媒中での酵素触媒不斉反応の設計と光学活性医薬品合成への応用
• ASYMMETRIC SYNTHESIS OF A CHIRAL NORBORNENE DERIVATIVE BY LIPASE-CATALYZED TRANSESTERIFICATION OF CIS- ENDO-5-NORBORNENE-2,3-DIMETHANOL AND ITS APPLICATION TO THE SYNTHESIS OF AN OPTICALLY ACTIVE TXA_2 ANTAGONIST
• SYNTHESIS OF BIOLOGICALLY ACTIVE ACYCLOAZT DERIVATIVES AND RELATED COMPOUNDS
• 不斉点から離れた位置に官能基を持つ化合物における酵素触媒不斉反応

もっと見る 閉じる

スポンサーリンク