Effect of Hydrophobically-Modified Hydroxypropyl Methylcellulose on the Crystallization from Supersaturated Solutions of Indomethacin
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概要
- 論文の詳細を見る
Hydrophobically-modified hydroxypropyl methylcellulose (HM-HPMC), possessing long-chain alkyl groups, is a new thickening agent for gel preparations. The solubility of indomethacin (IM) in supersaturated solutions increased with HM-HPMC concentration, but HM-HPMC did not solubilize IM crystals. This is not due to the suppression of the transformation of IM crystals from α to γ. HM-HPMC would thus appear to suppress the crystallization of IM from supersaturated solutions. Nucleation and crystal growth rates in a supersaturated solution of IM in the absence and presence of HM-HPMC were determined by measuring light transmittance under cooling. It became clear that HM-HPMC caused a slight stimulation of nucleation and a strong suppression of crystal growth. This activity of HM-HPMC was derived from the original polymer, HPMC, but was greater than that of HPMC itself. The suppression of crystal growth by HM-HPMC may thus be due to the hydrophobic interaction between hydrophobic regions, particularly long-chain alkyl groups, and IM molecules.
- 社団法人日本薬学会の論文
- 1994-11-15
著者
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池田 潔
School Of Pharmaceutical Sciences University Of Shizuoka
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尾熊 隆嘉
塩野義製薬株式会社 新薬研究所
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尾熊 隆嘉
Faculty Of Pharmaceutical Sciences University Of Tokyo
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高岸 靖
塩野義製薬新薬研究所
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高岸 靖
Developmental Research Laboratories Shionogi & Co. Ltd.
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池田 潔
Tanabe Seiyaku Co. Ltd. Saitama Jpn
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斎藤 泉
Developmental Research Laboratories Shionogi & Co. Ltd.
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Oguma T
Developmental Research Laboratories Shionogi & Co. Ltd.
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池田 かおり
Developmental Research Laboratories, Shionogi & Co., Ltd.,
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尾熊 隆嘉
Developmental Research Labotatories, Shionogi & Co., Ltd.,
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Oguma Takayoshi
Developmental Research Laboratories Shionogi & Co. Ltd.
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Takagishi Y
Developmental Research Laboratories Shionogi & Co. Ltd.
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池田 かおり
Developmental Research Laboratories Shionogi & Co. Ltd.
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Saitoh I
Shionogi & Co. Ltd. Hyogo Jpn
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尾熊 隆嘉
Developmental Research Labotatories Shionogi & Co. Ltd.
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斎藤 泉
Development Research Laboratories, Shionogi & Co., Ltd.,
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