High-Performance Liquid Chromatographic Analysis of Lactone and Hydroxy Acid of New Antitumor Drug, DX-8951(Exatecan), in Mouse Plasma
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概要
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A sensitive high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of lactone and total drug (lactone plus hydroxy-acid) of DX-8951 in mouse plasma. Solidphase extraction by C18 cartridge separated lactone from total drug of DX-8951. Analysis was performed using a reverse-phase ODS column with a mobile phase consisting of acetonitrile/0.05M potassium dihydrogen phosphate (pH3) (18:82, v/v) at a flow rate of 1ml/min. The limits of quantitation of lactone and total drug were 3ng/ml in plasma and a linear range of determination were observed over the concentration of 3 to 500ng/ml. This method was applied to pharmacokinetic study in male mice treated with a single intravenous administration of either lactone or hydroxy-acid of DX-8951. The plasma concentrations of lactone from 2 to 6h after dosing were similar regardless of the form of DX-8951 administered.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
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今野 勉
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
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Oguma T
Developmental Research Laboratories Shionogi & Co. Ltd.
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Oguma Takayoshi
Developmental Research Laboratories Shionogi & Co. Ltd.
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Konno T
Drug Metabolism & Physicochemical Property Research Laboratory Daiichi Pharmaceutical Co. Ltd.
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OGUMA Toshihiro
Drug Metabolism & Physicochemical Property Research Laboratory, Daiichi Pharmaceutical Co. Ltd.
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KONNO Tomomi
Drug Metabolism & Physicochemical Property Research Laboratory, Daiichi Pharmaceutical Co. Ltd.
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NAKAOKA Minoru
Drug Metabolism & Physicochemical Property Research Laboratory, Daiichi Pharmaceutical Co. Ltd.
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YAMADA Masayoshi
Drug Metabolism & Physicochemical Property Research Laboratory, Daiichi Pharmaceutical Co., Ltd.
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INUKAI Kazuyoshi
Drug Metabolism & Physicochemical Property Research Laboratory, Daiichi Pharmaceutical Co., Ltd.
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Yamada M
Drug Metabolism & Physicochemical Property Research Laboratory Daiichi Pharmaceutical Co. Ltd.
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Nakaoka Minoru
Drug Metabolism & Physicochemical Property Research Laboratory Daiichi Pharmaceutical Co. Ltd.
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Inukai Kazuyoshi
Drug Metabolism & Physicochemical Property Research Laboratory Daiichi Pharmaceutical Co. Ltd.
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