Physical and Chemical Changes of Medicinals in Mixtures with Adsorbents in the Solid State. I. : Effect of Vapor Pressure of the Medicinals on Changes in Crystalline Properties
スポンサーリンク
概要
- 論文の詳細を見る
It was found that some organic crystalline medicinals such as aspirin and phenacetin, when mixed with an adsorbent, gradually become amorphous during storage at room temperature (25℃). Concomitantly, they show different dissolution patterns and decreased chemical stability. The following observations suggest that this phenomenon takes place via the gaseous phase, induced by the vapor pressure of the medicinal themselves. (1) Subliming crystals such as naphthalene become amorphous immediately in mixtures with adsorbents. (2) The rate of change of medicinals to the amorphous state is accelerated under reduced pressure in these systems. (3) The rate of change of the crystals to the amorphous state increases with their vapor pressure. The technique of treating crystalline medicinals at reduced pressure with an adsorbent may be a useful method of obtaining medicinals in the amorphous state without employing either solvents or excessive thermal or mechanical energy.
- 社団法人日本薬学会の論文
- 1986-01-25
著者
-
今野 勉
Developmental Research Laboratories Daiichi Pharmaceutical Co. Ltd.
-
絹野 浩二
Pharmaceutical Formulation Research Center
-
今野 勉
Pharmaceutical Formulation Research Center, Research Institute, Daiichi Seiyaku Co., Ltd.,
-
片岡 捷夫
Pharmaceutical Formulation Research Center, Research Institute, Daiichi Seiyaku Co., Ltd.,
-
絹野 浩二
Pharmaceutical Formulation Research Center:research Institute Daiichi Seiyaku Co. Ltd.
-
Konno T
Drug Metabolism & Physicochemical Property Research Laboratory Daiichi Pharmaceutical Co. Ltd.
-
片岡 捷夫
Pharmaceutical Formulation Research Center Research Institute Daiichi Seiyaku Co. Ltd.
関連論文
- Effects of Grinding on the Physical and Chemical Properties of Crystalline Medicinals with Microcrystalline Cellulose V : Comparison with Tri-O-methyl-β-cyclodextrin Ground Mixtures
- Effects of Grinding on the Physical and Chemical Properties of Crystalline Medicinals with Microcrystalline Cellulose. IV. Comparison of the IR Spectra of Medicinals in the Solid State and in Solution
- Effects of Grinding on Physical and Chemical Properties of Crystalline Medicinals with Microcrystalline Cellulose. III. Infrared Spectra of Medicinals in Ground Mixtures
- Preliminary Preformulation Studies of a 2-(3,4-Dimethoxyphenyl)ethylamine Derivative for Oral Administration at an Exploratory Stage of New Drug Development
- Physical and Chemical Changes of Medicinals in Mixtures with Adsorbents in the Solid State. IV. : Study on Reduced-Pressure Mixing for Practical Use of Amorphous Mixtures of Flufenamic Acid
- Physical and Chemical Changes of Medicinals in Mixtures with Adsorbents in the Solid State. III. : Determination of Vapor Pressure of Solid Drugs by Steam Distillation
- Physical and Chemical Changes of Medicinals in Mixtures with Adsorbents in the Solid State. II. : Application of Reduced Pressure Treatment for the Improvement of Dissolution of Flufenamic Acid
- Physical and Chemical Changes of Medicinals in Mixtures with Adsorbents in the Solid State. I. : Effect of Vapor Pressure of the Medicinals on Changes in Crystalline Properties
- Effect of Crystallinity on the Percutaneous Absorption of Corticosteroid. I. Determination of the Degree of Crystallinity of Hydrocortisone Acetate in Ground Mixtures with Crystalline Cellulose
- Validation study of assay method for DE-310, a novel polymer-bound camptothecin derivative, and the free drug in mouse plasma by liquid chromatography with fluorimetric detection
- High-Performance Liquid Chromatographic Analysis of Lactone and Hydroxy Acid of New Antitumor Drug, DX-8951(Exatecan), in Mouse Plasma